Next Article in Journal
SD118-Xanthocillin X (1), a Novel Marine Agent Extracted from Penicillium commune, Induces Autophagy through the Inhibition of the MEK/ERK Pathway
Previous Article in Journal
New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea
Mar. Drugs 2012, 10(6), 1331-1344; doi:10.3390/md10061331
Article

Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral Sinularia sp. and Their Antifouling Activity

1
, 2
, 1
, 3
, 4
 and 1,*
1 State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China 2 China National Center for Biotechnology Development, Beijing 100036, China 3 National Museum of Natural History Naturalis, 2300 RA, Leiden 9515, The Netherlands 4 Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Duesseldorf 40225, Germany
* Author to whom correspondence should be addressed.
Received: 12 March 2012 / Revised: 16 April 2012 / Accepted: 4 June 2012 / Published: 11 June 2012
View Full-Text   |   Download PDF [1180 KB, uploaded 24 February 2015]   |   Browse Figures

Abstract

Nine new compounds, namely sinularones A–I (19), characterized as cyclopentenone and butenolide-type analogues, were isolated from a soft coral Sinularia sp., together with a known butenolide (10). Their structures were elucidated by means of spectroscopic (IR, MS, 1D and 2D NMR, CD) analysis. The absolute configurations were determined on the basis of CD and specific rotation data in association with the computed electronic circular dichroism (ECD) by time dependent density functional theory (TD DFT) at 6-31+G(d,p)//DFT B3LYP/6-31+G(d,p) level. Compounds 12 and 710 showed potent antifouling activities against the barnacle Balanus amphitrite.
Keywords: soft coral; Sinularia sp.; sinularones A–I; structural elucidation; antifouling activity soft coral; Sinularia sp.; sinularones A–I; structural elucidation; antifouling activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Shi, H.; Yu, S.; Liu, D.; van Ofwegen, L.; Proksch, P.; Lin, W. Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral Sinularia sp. and Their Antifouling Activity. Mar. Drugs 2012, 10, 1331-1344.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert