Mar. Drugs 2012, 10(6), 1331-1344; doi:10.3390/md10061331
Article

Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral Sinularia sp. and Their Antifouling Activity

1 State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China 2 China National Center for Biotechnology Development, Beijing 100036, China 3 National Museum of Natural History Naturalis, 2300 RA, Leiden 9515, The Netherlands 4 Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Duesseldorf 40225, Germany
* Author to whom correspondence should be addressed.
Received: 12 March 2012; in revised form: 16 April 2012 / Accepted: 4 June 2012 / Published: 11 June 2012
PDF Full-text Download PDF Full-Text [1180 KB, uploaded 11 June 2012 11:06 CEST]
Abstract: Nine new compounds, namely sinularones A–I (19), characterized as cyclopentenone and butenolide-type analogues, were isolated from a soft coral Sinularia sp., together with a known butenolide (10). Their structures were elucidated by means of spectroscopic (IR, MS, 1D and 2D NMR, CD) analysis. The absolute configurations were determined on the basis of CD and specific rotation data in association with the computed electronic circular dichroism (ECD) by time dependent density functional theory (TD DFT) at 6-31+G(d,p)//DFT B3LYP/6-31+G(d,p) level. Compounds 12 and 710 showed potent antifouling activities against the barnacle Balanus amphitrite.
Keywords: soft coral; Sinularia sp.; sinularones A–I; structural elucidation; antifouling activity

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Shi, H.; Yu, S.; Liu, D.; van Ofwegen, L.; Proksch, P.; Lin, W. Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral Sinularia sp. and Their Antifouling Activity. Mar. Drugs 2012, 10, 1331-1344.

AMA Style

Shi H, Yu S, Liu D, van Ofwegen L, Proksch P, Lin W. Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral Sinularia sp. and Their Antifouling Activity. Marine Drugs. 2012; 10(6):1331-1344.

Chicago/Turabian Style

Shi, Haiyan; Yu, Shanjiang; Liu, Dong; van Ofwegen, Leen; Proksch, Peter; Lin, Wenhan. 2012. "Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral Sinularia sp. and Their Antifouling Activity." Mar. Drugs 10, no. 6: 1331-1344.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert