Mar. Drugs 2012, 10(6), 1331-1344; doi:10.3390/md10061331
Article

Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral Sinularia sp. and Their Antifouling Activity

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Received: 12 March 2012; in revised form: 16 April 2012 / Accepted: 4 June 2012 / Published: 11 June 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Nine new compounds, namely sinularones A–I (19), characterized as cyclopentenone and butenolide-type analogues, were isolated from a soft coral Sinularia sp., together with a known butenolide (10). Their structures were elucidated by means of spectroscopic (IR, MS, 1D and 2D NMR, CD) analysis. The absolute configurations were determined on the basis of CD and specific rotation data in association with the computed electronic circular dichroism (ECD) by time dependent density functional theory (TD DFT) at 6-31+G(d,p)//DFT B3LYP/6-31+G(d,p) level. Compounds 12 and 710 showed potent antifouling activities against the barnacle Balanus amphitrite.
Keywords: soft coral; Sinularia sp.; sinularones A–I; structural elucidation; antifouling activity
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MDPI and ACS Style

Shi, H.; Yu, S.; Liu, D.; van Ofwegen, L.; Proksch, P.; Lin, W. Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral Sinularia sp. and Their Antifouling Activity. Mar. Drugs 2012, 10, 1331-1344.

AMA Style

Shi H, Yu S, Liu D, van Ofwegen L, Proksch P, Lin W. Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral Sinularia sp. and Their Antifouling Activity. Marine Drugs. 2012; 10(6):1331-1344.

Chicago/Turabian Style

Shi, Haiyan; Yu, Shanjiang; Liu, Dong; van Ofwegen, Leen; Proksch, Peter; Lin, Wenhan. 2012. "Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral Sinularia sp. and Their Antifouling Activity." Mar. Drugs 10, no. 6: 1331-1344.


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