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New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea
School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Rd. Sec. 1, Taipei 101-200, Taiwan
Institute of Marine Biotechnology and Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung 80424, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
* Author to whom correspondence should be addressed.
Received: 29 March 2012; in revised form: 18 May 2012 / Accepted: 29 May 2012 / Published: 7 June 2012
Abstract: Chemical investigation of Junceella juncea has resulted in the isolation of three new briaranes designated juncenolides M–O (1–3). The structures of these compounds were determined by spectroscopic analysis including 2D-NMR (COSY, HMBC and NOESY) and HRMS. Compound 1 is a new chlorinated briarane while compound 3 contains a rare methyl ester at C-16. The anti-inflammatory activities tested on superoxide anion generation and elastase release by human neutrophils in response to FMLP/CB were evaluated.
Keywords: Junceella juncea; briaranes; anti-inflammatory activity
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Chang, J.-Y.; Liaw, C.-C.; Fazary, A.E.; Hwang, T.-L.; Shen, Y.-C. New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea. Mar. Drugs 2012, 10, 1321-1330.
Chang J-Y, Liaw C-C, Fazary AE, Hwang T-L, Shen Y-C. New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea. Marine Drugs. 2012; 10(6):1321-1330.
Chang, Jiun-Yang; Liaw, Chia-Ching; Fazary, Ahmed Eid; Hwang, Tsong-Long; Shen, Ya-Ching. 2012. "New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea." Mar. Drugs 10, no. 6: 1321-1330.