Mar. Drugs 2012, 10(6), 1203-1211; doi:10.3390/md10061203
Article

Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex

Shwu-Li Wu 1,2 email, Jui-Hsin Su 3,4 email, Chiung-Yao Huang 1 email, Chi-Jen Tai 1 email, Ping-Jyun Sung 3,4 email, Chih-Chung Liaw 1 email and Jyh-Horng Sheu 1,5,* email
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 Center of General Studies, National Kaohsiung Marine University, Kaohsiung 811, Taiwan 3 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 4 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 5 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 27 April 2012; in revised form: 18 May 2012 / Accepted: 22 May 2012 / Published: 25 May 2012
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Abstract: Four new eunicellin-based diterpenes, simplexins P–S (1–4), and the known compound simplexin A (5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 3–5 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic.
Keywords: soft coral; eunicellin-based diterpenes; cytotoxicity; Klyxum simplex

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MDPI and ACS Style

Wu, S.-L.; Su, J.-H.; Huang, C.-Y.; Tai, C.-J.; Sung, P.-J.; Liaw, C.-C.; Sheu, J.-H. Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex. Mar. Drugs 2012, 10, 1203-1211.

AMA Style

Wu S-L, Su J-H, Huang C-Y, Tai C-J, Sung P-J, Liaw C-C, Sheu J-H. Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex. Marine Drugs. 2012; 10(6):1203-1211.

Chicago/Turabian Style

Wu, Shwu-Li; Su, Jui-Hsin; Huang, Chiung-Yao; Tai, Chi-Jen; Sung, Ping-Jyun; Liaw, Chih-Chung; Sheu, Jyh-Horng. 2012. "Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex." Mar. Drugs 10, no. 6: 1203-1211.

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