Mar. Drugs 2012, 10(6), 1203-1211; doi:10.3390/md10061203
Article

Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex

1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 Center of General Studies, National Kaohsiung Marine University, Kaohsiung 811, Taiwan 3 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 4 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 5 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 27 April 2012; in revised form: 18 May 2012 / Accepted: 22 May 2012 / Published: 25 May 2012
PDF Full-text Download PDF Full-Text [389 KB, uploaded 25 May 2012 16:27 CEST]
Abstract: Four new eunicellin-based diterpenes, simplexins P–S (14), and the known compound simplexin A (5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 35 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic.
Keywords: soft coral; eunicellin-based diterpenes; cytotoxicity; Klyxum simplex

Supplementary Files and Correction

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Wu, S.-L.; Su, J.-H.; Huang, C.-Y.; Tai, C.-J.; Sung, P.-J.; Liaw, C.-C.; Sheu, J.-H. Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex. Mar. Drugs 2012, 10, 1203-1211.

AMA Style

Wu S-L, Su J-H, Huang C-Y, Tai C-J, Sung P-J, Liaw C-C, Sheu J-H. Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex. Marine Drugs. 2012; 10(6):1203-1211.

Chicago/Turabian Style

Wu, Shwu-Li; Su, Jui-Hsin; Huang, Chiung-Yao; Tai, Chi-Jen; Sung, Ping-Jyun; Liaw, Chih-Chung; Sheu, Jyh-Horng. 2012. "Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex." Mar. Drugs 10, no. 6: 1203-1211.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert