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Correction published on 13 December 2013, see Mar. Drugs 2013, 11(12), 5087-5088.

Mar. Drugs 2012, 10(6), 1203-1211; doi:10.3390/md10061203
Article

Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex

1,2
,
3,4
,
1
,
1
,
3,4
,
1
 and
1,5,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 Center of General Studies, National Kaohsiung Marine University, Kaohsiung 811, Taiwan 3 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 4 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 5 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 27 April 2012 / Revised: 18 May 2012 / Accepted: 22 May 2012 / Published: 25 May 2012
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Abstract

Four new eunicellin-based diterpenes, simplexins P–S (14), and the known compound simplexin A (5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 35 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic.
Keywords: soft coral; eunicellin-based diterpenes; cytotoxicity; Klyxum simplex soft coral; eunicellin-based diterpenes; cytotoxicity; Klyxum simplex
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wu, S.-L.; Su, J.-H.; Huang, C.-Y.; Tai, C.-J.; Sung, P.-J.; Liaw, C.-C.; Sheu, J.-H. Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex. Mar. Drugs 2012, 10, 1203-1211.

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