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Mar. Drugs 2012, 10(5), 987-997; doi:10.3390/md10050987

Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.

1 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 2 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan 3 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 4 Institute of Marine Biology, National Sun Yat-sen University, Kaohsiung 804, Taiwan 5 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 6 Eastern Marine Biology Research Center, Fisheries Research Institute, Taitung 961, Taiwan
* Author to whom correspondence should be addressed.
Received: 28 March 2012 / Revised: 18 April 2012 / Accepted: 24 April 2012 / Published: 27 April 2012
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One new pentacyclic sesterterpene, hippospongide A (1), and one new scalarane sesterterpenoid, hippospongide B (2), along with six previously reported known scalarane–type sesterterpenes (38), were isolated from a sponge Hippospongia sp. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. These metabolites are the first pentacyclic sesterterpene and scalarane-type sesterterpenes to be reported from this genus. Compounds 35 exhibited significant cytotoxicity against DLD-1, HCT-116, T-47D and K562 cancer cell lines.
Keywords: sesterterpenoid; scalarane; sponge; Hippospongia sesterterpenoid; scalarane; sponge; Hippospongia
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Chang, Y.-C.; Tseng, S.-W.; Liu, L.-L.; Chou, Y.; Ho, Y.-S.; Lu, M.-C.; Su, J.-H. Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.. Mar. Drugs 2012, 10, 987-997.

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