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Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals
Department of Research and Food Science Graduate Program, University of Sonora, Apartado Postal 1658, Hermosillo, Sonora, Mexico
* Author to whom correspondence should be addressed.
Received: 31 December 2011; in revised form: 24 March 2012 / Accepted: 5 April 2012 / Published: 26 April 2012
Abstract: Biologically active compounds with different modes of action, such as, antiproliferative, antioxidant, antimicrotubule, have been isolated from marine sources, specifically algae and cyanobacteria. Recently research has been focused on peptides from marine animal sources, since they have been found as secondary metabolites from sponges, ascidians, tunicates, and mollusks. The structural characteristics of these peptides include various unusual amino acid residues which may be responsible for their bioactivity. Moreover, protein hydrolysates formed by the enzymatic digestion of aquatic and marine by-products are an important source of bioactive peptides. Purified peptides from these sources have been shown to have antioxidant activity and cytotoxic effect on several human cancer cell lines such as HeLa, AGS, and DLD-1. These characteristics imply that the use of peptides from marine sources has potential for the prevention and treatment of cancer, and that they might also be useful as molecular models in anticancer drug research. This review focuses on the latest studies and critical research in this field, and evidences the immense potential of marine animals as bioactive peptide sources.
Keywords: bioactive peptide; anticancer; antiproliferative; marine compounds
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Suarez-Jimenez, G.-M.; Burgos-Hernandez, A.; Ezquerra-Brauer, J.-M. Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals. Mar. Drugs 2012, 10, 963-986.
Suarez-Jimenez G-M, Burgos-Hernandez A, Ezquerra-Brauer J-M. Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals. Marine Drugs. 2012; 10(5):963-986.
Suarez-Jimenez, Guadalupe-Miroslava; Burgos-Hernandez, Armando; Ezquerra-Brauer, Josafat-Marina. 2012. "Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals." Mar. Drugs 10, no. 5: 963-986.