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Mar. Drugs 2012, 10(11), 2608-2617; doi:10.3390/md10112608
Article

seco-Briarellinone and Briarellin S, Two New Eunicellin-Based Diterpenoids from the Panamanian Octocoral Briareum asbestinum

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Received: 20 August 2012 / Revised: 26 September 2012 / Accepted: 22 October 2012 / Published: 21 November 2012
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Abstract

Two new eunicellin-based diterpenes, seco-briarellinone (1) and briarellin S (2), and a known seco-asbestinin (3) have been isolated from the methanolic extract of the common octocoral Briareum asbestinum collected in Bocas del Toro, Caribbean of Panama. The structures and relative stereochemistry of the compounds were defined using extensive spectroscopic analysis including 1D, 2D-nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS). Compounds 1 and 2 displayed anti-inflammatory properties inhibiting nitric oxide (NO) production induced by lipopolisacharide (LPS) in macrophages with an Inhibitory concentration 50% (IC50) of 4.7 μM and 20.3 μM, respectively. This is the first report of briarellin diterpenes containing a ketone group at C-12.
Keywords: Briareum asbestinum; seco-briarellins; briarellin diterpenes; seco-asbestinin diterpenes; anti-inflammatory properties Briareum asbestinum; seco-briarellins; briarellin diterpenes; seco-asbestinin diterpenes; anti-inflammatory properties
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gómez-Reyes, J.F.; Salazar, A.; Guzmán, H.M.; González, Y.; Fernández, P.L.; Ariza-Castolo, A.; Gutiérrez, M. seco-Briarellinone and Briarellin S, Two New Eunicellin-Based Diterpenoids from the Panamanian Octocoral Briareum asbestinum. Mar. Drugs 2012, 10, 2608-2617.

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