Mar. Drugs 2012, 10(10), 2337-2348; doi:10.3390/md10102337
Article

Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model

Kazuo Azuma 1 email, Toshitsugu Ishihara 1,† email, Hiroyuki Nakamoto 1,† email, Takao Amaha 1,† email, Tomohiro Osaki 1 email, Takeshi Tsuka 1 email, Tomohiro Imagawa 1 email, Saburo Minami 1 email, Osamu Takashima 2 email, Shinsuke Ifuku 3 email, Minoru Morimoto 3 email, Hiroyuki Saimoto 3 email, Hitoshi Kawamoto 4 email and Yoshiharu Okamoto 1,* email
1 Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori-shi, Tottori 680-8553, Japan 2 Scientific Crime Laboratory, Tottori Prefectural Police H. Q., 2-12 Chiyomi, Tottori 680-0911, Japan 3 The Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan 4 Marine Products Kimura Co., LTD., 3307 Watari-cho Sakaiminato-shi, Tottori 684-0072, Japan † These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 17 August 2012; in revised form: 10 September 2012 / Accepted: 11 October 2012 / Published: 22 October 2012
(This article belongs to the Special Issue Marine Glycoconjugates)
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Abstract: We evaluated the anti-tumor activities of the oral administration of fucoidan extracted from Cladosiphon okamuranus using a tumor (colon 26)-bearing mouse model. The materials used included low-molecular-weight fucoidan (LMWF: 6.5–40 kDa), intermediate-molecular-weight fucoidan (IMWF: 110–138 kDa) and high-molecular-weight fucoidan (HMWF: 300–330 kDa). The IMWF group showed significantly suppressed tumor growth. The LMWF and HMWF groups showed significantly increased survival times compared with that observed in the control group (mice fed a fucoidan-free diet). The median survival times in the control, LMWF, IMWF and HMWF groups were 23, 46, 40 and 43 days, respectively. It was also found that oral administration of fucoidan increased the population of natural killer cells in the spleen. Furthermore, from the results of the experiment using Myd-88 knockout mice, it was found that these effects are related to gut immunity. These results suggest that fucoidan is a candidate anti-tumor functional food.
Keywords: fucoidan; Cladosiphon okamuranu; anti-tumor activities; colon-26; mice; functional food

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Cite This Article

MDPI and ACS Style

Azuma, K.; Ishihara, T.; Nakamoto, H.; Amaha, T.; Osaki, T.; Tsuka, T.; Imagawa, T.; Minami, S.; Takashima, O.; Ifuku, S.; Morimoto, M.; Saimoto, H.; Kawamoto, H.; Okamoto, Y. Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model. Mar. Drugs 2012, 10, 2337-2348.

AMA Style

Azuma K, Ishihara T, Nakamoto H, Amaha T, Osaki T, Tsuka T, Imagawa T, Minami S, Takashima O, Ifuku S, Morimoto M, Saimoto H, Kawamoto H, Okamoto Y. Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model. Marine Drugs. 2012; 10(10):2337-2348.

Chicago/Turabian Style

Azuma, Kazuo; Ishihara, Toshitsugu; Nakamoto, Hiroyuki; Amaha, Takao; Osaki, Tomohiro; Tsuka, Takeshi; Imagawa, Tomohiro; Minami, Saburo; Takashima, Osamu; Ifuku, Shinsuke; Morimoto, Minoru; Saimoto, Hiroyuki; Kawamoto, Hitoshi; Okamoto, Yoshiharu. 2012. "Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model." Mar. Drugs 10, no. 10: 2337-2348.

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