Cytotoxic Activity of Semi-Synthetic Derivatives of Elatol and Isoobtusol
Abstract
:1. Introduction
2. Results and Discussion
2.1. Chemistry
2.2. Cytotoxic Activity
Compound | Cell lines [CC50a (μM)] | |
---|---|---|
A549 | RD | |
1 | 7.56 ± 0.19 | 11.22 ± 1.63 |
2 | 14.24 ± 3.43 | 6.24 ± 1.11 |
3 | 21.93 ± 1.27 | 13.26 ± 0.76 |
4 | 39.05 ± 4.81 | 21.23 ± 7.16 |
5 | >100 | 41.53 ± 0.36 |
6 | 39.57 ± 2.07 | 23.83 ± 5.28 |
7 | 10.74 ± 2.52 | 4.93 ± 0.52 |
8 | 23.85 ± 5.21 | 20.48 ± 1.44 |
Paclitaxel | 0.260 ± 0.027 | 0.025 ± 0.004 |
3. Experimental
3.1. General
3.2. Algal Material
3.3. Synthesis
3.3.1. Elatol 9-Carbamate (3)
3.3.2. Elatol 9-Hemisuccinate (4)
3.3.3. Elatol 9-Sulfamate (5)
3.3.4. Isoobtusol 9-Carbamate (6)
3.3.5. Isoobtusol 9-Hemisuccinate (7)
3.3.6. Isoobtusol 9-Sulfamate (8)
3.4. Cell Lines
3.5. MTT Assay
3.6. Statistical Analysis
4. Conclusions
Acknowledgements
References
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Lang, K.L.; Silva, I.T.; Zimmermann, L.A.; Lhullier, C.; Mañalich Arana, M.V.; Palermo, J.A.; Falkenberg, M.; Simões, C.M.O.; Schenkel, E.P.; Durán, F.J. Cytotoxic Activity of Semi-Synthetic Derivatives of Elatol and Isoobtusol. Mar. Drugs 2012, 10, 2254-2264. https://doi.org/10.3390/md10102254
Lang KL, Silva IT, Zimmermann LA, Lhullier C, Mañalich Arana MV, Palermo JA, Falkenberg M, Simões CMO, Schenkel EP, Durán FJ. Cytotoxic Activity of Semi-Synthetic Derivatives of Elatol and Isoobtusol. Marine Drugs. 2012; 10(10):2254-2264. https://doi.org/10.3390/md10102254
Chicago/Turabian StyleLang, Karen L., Izabella T. Silva, Lara A. Zimmermann, Cíntia Lhullier, Maria V. Mañalich Arana, Jorge A. Palermo, Miriam Falkenberg, Cláudia M. O. Simões, Eloir P. Schenkel, and Fernando J. Durán. 2012. "Cytotoxic Activity of Semi-Synthetic Derivatives of Elatol and Isoobtusol" Marine Drugs 10, no. 10: 2254-2264. https://doi.org/10.3390/md10102254