Mar. Drugs 2012, 10(10), 2254-2264; doi:10.3390/md10102254
Article

Cytotoxic Activity of Semi-Synthetic Derivatives of Elatol and Isoobtusol

1 Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-970, Brazil 2 Department of Organic Chemistry, University of Buenos Aires, Buenos Aires, C1428EGA, Argentina
* Author to whom correspondence should be addressed.
Received: 1 August 2012; in revised form: 12 September 2012 / Accepted: 1 October 2012 / Published: 18 October 2012
PDF Full-text Download PDF Full-Text [456 KB, uploaded 18 October 2012 09:26 CEST]
Abstract: In the present study, the in vitro cytotoxic effects of six semi-synthetic derivatives of elatol (1) and isoobtusol (2) were investigated. Chemical modifications were performed on the hydroxyl groups aiming to get derivatives of different polarity, namely the hemisuccinate, carbamate and sulfamate. The structural elucidation of the new derivatives was based on detailed NMR and MS spectroscopic analyses. The in vitro cytotoxicity of compounds 1 to 8 was evaluated against A459 and RD tumor cell lines with CC50 values ranging from 4.93 to 41.53 µM. These results suggest that the structural modifications performed on both compounds could be considered a good strategy to obtain more active derivatives.
Keywords: elatol; isoobtusol; sesquiterpenes; synthesis; cytotoxic activity

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Lang, K.L.; Silva, I.T.; Zimmermann, L.A.; Lhullier, C.; Mañalich Arana, M.V.; Palermo, J.A.; Falkenberg, M.; Simões, C.M.O.; Schenkel, E.P.; Durán, F.J. Cytotoxic Activity of Semi-Synthetic Derivatives of Elatol and Isoobtusol. Mar. Drugs 2012, 10, 2254-2264.

AMA Style

Lang KL, Silva IT, Zimmermann LA, Lhullier C, Mañalich Arana MV, Palermo JA, Falkenberg M, Simões CMO, Schenkel EP, Durán FJ. Cytotoxic Activity of Semi-Synthetic Derivatives of Elatol and Isoobtusol. Marine Drugs. 2012; 10(10):2254-2264.

Chicago/Turabian Style

Lang, Karen L.; Silva, Izabella T.; Zimmermann, Lara A.; Lhullier, Cíntia; Mañalich Arana, Maria V.; Palermo, Jorge A.; Falkenberg, Miriam; Simões, Cláudia M. O.; Schenkel, Eloir P.; Durán, Fernando J. 2012. "Cytotoxic Activity of Semi-Synthetic Derivatives of Elatol and Isoobtusol." Mar. Drugs 10, no. 10: 2254-2264.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert