Next Article in Journal
Cytotoxic Activity of Semi-Synthetic Derivatives of Elatol and Isoobtusol
Previous Article in Journal
Biosynthetic Studies on Water-Soluble Derivative 5c (DTX5c)
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2012, 10(10), 2246-2253;

Echinohalimane A, a Bioactive Halimane-Type Diterpenoid from a Formosan Gorgonian Echinomuricea sp. (Plexauridae)

Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Authors to whom correspondence should be addressed.
Received: 5 September 2012 / Revised: 24 September 2012 / Accepted: 8 October 2012 / Published: 17 October 2012
View Full-Text   |   Download PDF [395 KB, uploaded 24 February 2015]   |  


A new halimane-type diterpenoid, echinohalimane A (1), was isolated from a gorgonian, identified as Echinomuricea sp. The structure of 1 was determined by spectroscopic methods and this compound was found to exhibit cytotoxicity toward various tumor cells and display an inhibitory effect on the release of elastase by human neutrophils. Echinohalimane A (1) is the first halimane analogue from the marine organisms belonging to phylum Cnidaria. View Full-Text
Keywords: halimane; echinohalimane; Echinomuricea; cytotoxicity; elastase halimane; echinohalimane; Echinomuricea; cytotoxicity; elastase

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Chung, H.-M.; Hu, L.-C.; Yen, W.-H.; Su, J.-H.; Lu, M.-C.; Hwang, T.-L.; Wang, W.-H.; Sung, P.-J. Echinohalimane A, a Bioactive Halimane-Type Diterpenoid from a Formosan Gorgonian Echinomuricea sp. (Plexauridae). Mar. Drugs 2012, 10, 2246-2253.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top