Next Article in Journal
Cytotoxic Activity of Semi-Synthetic Derivatives of Elatol and Isoobtusol
Previous Article in Journal
Biosynthetic Studies on Water-Soluble Derivative 5c (DTX5c)
Mar. Drugs 2012, 10(10), 2246-2253; doi:10.3390/md10102246
Article

Echinohalimane A, a Bioactive Halimane-Type Diterpenoid from a Formosan Gorgonian Echinomuricea sp. (Plexauridae)

1,2
, 2,3
, 2,3
, 1,2,3
, 2,3
, 4
, 1,2,*  and 1,2,3,*
Received: 5 September 2012; in revised form: 24 September 2012 / Accepted: 8 October 2012 / Published: 17 October 2012
View Full-Text   |   Download PDF [395 KB, uploaded 17 October 2012]   |   Browse Figures
Abstract: A new halimane-type diterpenoid, echinohalimane A (1), was isolated from a gorgonian, identified as Echinomuricea sp. The structure of 1 was determined by spectroscopic methods and this compound was found to exhibit cytotoxicity toward various tumor cells and display an inhibitory effect on the release of elastase by human neutrophils. Echinohalimane A (1) is the first halimane analogue from the marine organisms belonging to phylum Cnidaria.
Keywords: halimane; echinohalimane; Echinomuricea; cytotoxicity; elastase halimane; echinohalimane; Echinomuricea; cytotoxicity; elastase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Chung, H.-M.; Hu, L.-C.; Yen, W.-H.; Su, J.-H.; Lu, M.-C.; Hwang, T.-L.; Wang, W.-H.; Sung, P.-J. Echinohalimane A, a Bioactive Halimane-Type Diterpenoid from a Formosan Gorgonian Echinomuricea sp. (Plexauridae). Mar. Drugs 2012, 10, 2246-2253.

AMA Style

Chung H-M, Hu L-C, Yen W-H, Su J-H, Lu M-C, Hwang T-L, Wang W-H, Sung P-J. Echinohalimane A, a Bioactive Halimane-Type Diterpenoid from a Formosan Gorgonian Echinomuricea sp. (Plexauridae). Marine Drugs. 2012; 10(10):2246-2253.

Chicago/Turabian Style

Chung, Hsu-Ming; Hu, Li-Chung; Yen, Wei-Hsuan; Su, Jui-Hsin; Lu, Mei-Chin; Hwang, Tsong-Long; Wang, Wei-Hsien; Sung, Ping-Jyun. 2012. "Echinohalimane A, a Bioactive Halimane-Type Diterpenoid from a Formosan Gorgonian Echinomuricea sp. (Plexauridae)." Mar. Drugs 10, no. 10: 2246-2253.


Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert