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Mar. Drugs 2012, 10(10), 2246-2253; doi:10.3390/md10102246

Echinohalimane A, a Bioactive Halimane-Type Diterpenoid from a Formosan Gorgonian Echinomuricea sp. (Plexauridae)

1,2,*  and 1,2,3,*
1 Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 3 Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 4 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
* Authors to whom correspondence should be addressed.
Received: 5 September 2012 / Revised: 24 September 2012 / Accepted: 8 October 2012 / Published: 17 October 2012
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A new halimane-type diterpenoid, echinohalimane A (1), was isolated from a gorgonian, identified as Echinomuricea sp. The structure of 1 was determined by spectroscopic methods and this compound was found to exhibit cytotoxicity toward various tumor cells and display an inhibitory effect on the release of elastase by human neutrophils. Echinohalimane A (1) is the first halimane analogue from the marine organisms belonging to phylum Cnidaria.
Keywords: halimane; echinohalimane; Echinomuricea; cytotoxicity; elastase halimane; echinohalimane; Echinomuricea; cytotoxicity; elastase
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chung, H.-M.; Hu, L.-C.; Yen, W.-H.; Su, J.-H.; Lu, M.-C.; Hwang, T.-L.; Wang, W.-H.; Sung, P.-J. Echinohalimane A, a Bioactive Halimane-Type Diterpenoid from a Formosan Gorgonian Echinomuricea sp. (Plexauridae). Mar. Drugs 2012, 10, 2246-2253.

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