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Mar. Drugs 2012, 10(10), 2234-2245; doi:10.3390/md10102234
Article

Biosynthetic Studies on Water-Soluble Derivative 5c (DTX5c)

1
, 1,2
, 1,3,*  and 1,2,*
1 University Institute for Bio-Organic Chemistry “Antonio González”, University of La Laguna, Av. Astrofísico Francisco Sánchez 2, La Laguna 38206, Spain 2 Department of Organic Chemistry, Faculty of Pharmacy, University of La Laguna, Av. Astrofísico Francisco Sánchez s/n, La Laguna 38206, Spain 3 Department of Chemical Engineering and Pharmaceutical Technology, Faculty of Pharmacy, University of La Laguna, Av. Astrofísico Francisco Sánchez s/n, La Laguna 38206, Spain
* Authors to whom correspondence should be addressed.
Received: 10 August 2012 / Revised: 18 September 2012 / Accepted: 20 September 2012 / Published: 12 October 2012
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Abstract

The dinoflagellate Prorocentrum belizeanum is responsible for the production of several toxins involved in the red tide phenomenon known as Diarrhetic Shellfish Poisoning (DSP). In this paper we report on the biosynthetic origin of an okadaic acid water-soluble ester derivative, DTX5c, on the basis of the spectroscopical analysis of 13C enriched samples obtained by addition of labelled sodium [l-13C], [2-13C] acetate to artificial cultures of this dinoflagellate.
Keywords: biosynthesis; marine toxin; DSP; marine polyether; polyketide biosynthesis; marine toxin; DSP; marine polyether; polyketide
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Vilches, T.S.; Norte, M.; Daranas, A.H.; Fernández, J.J. Biosynthetic Studies on Water-Soluble Derivative 5c (DTX5c). Mar. Drugs 2012, 10, 2234-2245.

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