Mar. Drugs 2012, 10(10), 2234-2245; doi:10.3390/md10102234
Article

Biosynthetic Studies on Water-Soluble Derivative 5c (DTX5c)

Tamara S. Vilches 1 email, Manuel Norte 1,2 email, Antonio Hernández Daranas 1,3,* email and José J. Fernández 1,2,* email
1 University Institute for Bio-Organic Chemistry “Antonio González”, University of La Laguna, Av. Astrofísico Francisco Sánchez 2, La Laguna 38206, Spain 2 Department of Organic Chemistry, Faculty of Pharmacy, University of La Laguna, Av. Astrofísico Francisco Sánchez s/n, La Laguna 38206, Spain 3 Department of Chemical Engineering and Pharmaceutical Technology, Faculty of Pharmacy, University of La Laguna, Av. Astrofísico Francisco Sánchez s/n, La Laguna 38206, Spain
* Authors to whom correspondence should be addressed.
Received: 10 August 2012; in revised form: 18 September 2012 / Accepted: 20 September 2012 / Published: 12 October 2012
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Abstract: The dinoflagellate Prorocentrum belizeanum is responsible for the production of several toxins involved in the red tide phenomenon known as Diarrhetic Shellfish Poisoning (DSP). In this paper we report on the biosynthetic origin of an okadaic acid water-soluble ester derivative, DTX5c, on the basis of the spectroscopical analysis of 13C enriched samples obtained by addition of labelled sodium [l-13C], [2-13C] acetate to artificial cultures of this dinoflagellate.
Keywords: biosynthesis; marine toxin; DSP; marine polyether; polyketide

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MDPI and ACS Style

Vilches, T.S.; Norte, M.; Daranas, A.H.; Fernández, J.J. Biosynthetic Studies on Water-Soluble Derivative 5c (DTX5c). Mar. Drugs 2012, 10, 2234-2245.

AMA Style

Vilches TS, Norte M, Daranas AH, Fernández JJ. Biosynthetic Studies on Water-Soluble Derivative 5c (DTX5c). Marine Drugs. 2012; 10(10):2234-2245.

Chicago/Turabian Style

Vilches, Tamara S.; Norte, Manuel; Daranas, Antonio H.; Fernández, José J. 2012. "Biosynthetic Studies on Water-Soluble Derivative 5c (DTX5c)." Mar. Drugs 10, no. 10: 2234-2245.

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