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Mar. Drugs 2012, 10(10), 2234-2245; doi:10.3390/md10102234

Biosynthetic Studies on Water-Soluble Derivative 5c (DTX5c)

1,3,*  and 1,2,*
Received: 10 August 2012 / Revised: 18 September 2012 / Accepted: 20 September 2012 / Published: 12 October 2012
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The dinoflagellate Prorocentrum belizeanum is responsible for the production of several toxins involved in the red tide phenomenon known as Diarrhetic Shellfish Poisoning (DSP). In this paper we report on the biosynthetic origin of an okadaic acid water-soluble ester derivative, DTX5c, on the basis of the spectroscopical analysis of 13C enriched samples obtained by addition of labelled sodium [l-13C], [2-13C] acetate to artificial cultures of this dinoflagellate.
Keywords: biosynthesis; marine toxin; DSP; marine polyether; polyketide biosynthesis; marine toxin; DSP; marine polyether; polyketide
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Vilches, T.S.; Norte, M.; Daranas, A.H.; Fernández, J.J. Biosynthetic Studies on Water-Soluble Derivative 5c (DTX5c). Mar. Drugs 2012, 10, 2234-2245.

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