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Anti-Human Rhinoviral Activity of Polybromocatechol Compounds Isolated from the Rhodophyta, Neorhodomela aculeata
Marine Chemomics Lab., Natural Medicine Center, Korea Institute of Science and Technology, Gangneung 210-340, Korea
Zoonosis Research Center, Wonkwang University College of Medicine & Oriental Medicine, 344-2, Iksan, Chonbuk 570-749, Korea
Department of Microbiology and Basic Science, Kwandong University College of Medicine, Gangneung 210-701, Korea
Immune Modulator Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Korea
These authors contributed equally to this work.
Current address: Division of Enteric and Hepatitis Viruses, Center for Infectious Diseases, National Institute of Health, Korea Center for Disease Control and Prevention, Osong 363-951, Korea.
* Authors to whom correspondence should be addressed.
Received: 29 June 2012; in revised form: 24 August 2012 / Accepted: 25 September 2012 / Published: 10 October 2012
Abstract: An extract of the red alga, Neorhodomela aculeata, exhibited antiviral activity against human rhinoviruses. Bioassay-guided purification was performed to yield six compounds, which were subsequently identified as lanosol (1) and five polybromocatechols (2–6) by spectroscopic methods, including 1D and 2D NMR and mass spectrometric analyses. Structurally, all of these compounds, except compound 5, contain one or two 2,3-dibromo-4,5-dihydroxyphenyl moieties. In a biological activity assay, compound 1 was found to possess antiviral activity with a 50% inhibitory concentration (IC50) of 2.50 μg/mL against HRV2. Compound 3 showed anti-HRV2 activity, with an IC50 of 7.11 μg/mL, and anti-HRV3 activity, with an IC50 of 4.69 μg/mL, without demonstrable cytotoxicity at a concentration of 20 μg/mL. Collectively, the results suggest that compounds 1 and 3 are candidates for novel therapeutics against two different groups of human rhinovirus.
Keywords: Neorhodomela aculeate; red alga; polybromocatechol compounds; antiviral activity; human rhinovirus
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Park, S.-H.; Song, J.-H.; Kim, T.; Shin, W.-S.; Park, G.M.; Lee, S.; Kim, Y.-J.; Choi, P.; Kim, H.; Kim, H.-S.; Kwon, D.-H.; Choi, H.J.; Ham, J. Anti-Human Rhinoviral Activity of Polybromocatechol Compounds Isolated from the Rhodophyta, Neorhodomela aculeata. Mar. Drugs 2012, 10, 2222-2233.
Park S-H, Song J-H, Kim T, Shin W-S, Park GM, Lee S, Kim Y-J, Choi P, Kim H, Kim H-S, Kwon D-H, Choi HJ, Ham J. Anti-Human Rhinoviral Activity of Polybromocatechol Compounds Isolated from the Rhodophyta, Neorhodomela aculeata. Marine Drugs. 2012; 10(10):2222-2233.
Park, Soon-Hye; Song, Jae-Hyoung; Kim, Taejung; Shin, Woon-Seob; Park, Gab Man; Lee, Seokjoon; Kim, Young-Joo; Choi, Pilju; Kim, Heejin; Kim, Hui-Seong; Kwon, Dur-Han; Choi, Hwa Jung; Ham, Jungyeob. 2012. "Anti-Human Rhinoviral Activity of Polybromocatechol Compounds Isolated from the Rhodophyta, Neorhodomela aculeata." Mar. Drugs 10, no. 10: 2222-2233.