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Mar. Drugs 2003, 1(1), 46-53; doi:10.3390/md101046
Article

Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity

 and *
Received: 13 October 2003; Accepted: 13 November 2003 / Published: 26 November 2003
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Abstract: Two new long-chain C33 polyacetylenic compounds, halicynones A and B were isolated from the marine sponge Haliclona sp. along with known analogs. The known compound pellynol A possessing a 1-yn-3-ol terminus, exhibited strong antitumor activity against the human colon tumor cell line HCT-116 (IC50 0.026 μg/mL), however, the corresponding 1-yn-3-one, halicynone A, was inactive, which suggests an important role for the terminal 1-yn-3-ol functional group in mediating cytotoxic activity.
Keywords: Porifera; ene-yne; HCT-116; cytotoxic activity; polyacetylene; pellynol Porifera; ene-yne; HCT-116; cytotoxic activity; polyacetylene; pellynol
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhou, G.-X.; Molinski, T.F. Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity. Mar. Drugs 2003, 1, 46-53.

AMA Style

Zhou G-X, Molinski TF. Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity. Marine Drugs. 2003; 1(1):46-53.

Chicago/Turabian Style

Zhou, Guang-Xiong; Molinski, Tadeusz F. 2003. "Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity." Mar. Drugs 1, no. 1: 46-53.



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