Next Article in Journal
Pseudopterosin Biosynthesis: Aromatization of the Diterpene Cyclase Product, Elisabethatriene
Previous Article in Journal
Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac
Mar. Drugs 2003, 1(1), 46-53; doi:10.3390/md101046
Article

Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity

 and *
Department of Chemistry, University of California, Davis, California 95616, USA
* Author to whom correspondence should be addressed.
Received: 13 October 2003 / Accepted: 13 November 2003 / Published: 26 November 2003
View Full-Text   |   Download PDF [149 KB, uploaded 24 February 2015]   |  

Abstract

Two new long-chain C33 polyacetylenic compounds, halicynones A and B were isolated from the marine sponge Haliclona sp. along with known analogs. The known compound pellynol A possessing a 1-yn-3-ol terminus, exhibited strong antitumor activity against the human colon tumor cell line HCT-116 (IC50 0.026 μg/mL), however, the corresponding 1-yn-3-one, halicynone A, was inactive, which suggests an important role for the terminal 1-yn-3-ol functional group in mediating cytotoxic activity.
Keywords: Porifera; ene-yne; HCT-116; cytotoxic activity; polyacetylene; pellynol Porifera; ene-yne; HCT-116; cytotoxic activity; polyacetylene; pellynol
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Zhou, G.-X.; Molinski, T.F. Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity. Mar. Drugs 2003, 1, 46-53.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert