Mar. Drugs 2003, 1(1), 46-53; doi:10.3390/md101046
Article

Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity

Guang-Xiong Zhou and Tadeusz F. Molinski* email
Department of Chemistry, University of California, Davis, California 95616, USA
* Author to whom correspondence should be addressed.
Received: 13 October 2003 / Accepted: 13 November 2003 / Published: 26 November 2003
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Abstract: Two new long-chain C33 polyacetylenic compounds, halicynones A and B were isolated from the marine sponge Haliclona sp. along with known analogs. The known compound pellynol A possessing a 1-yn-3-ol terminus, exhibited strong antitumor activity against the human colon tumor cell line HCT-116 (IC50 0.026 μg/mL), however, the corresponding 1-yn-3-one, halicynone A, was inactive, which suggests an important role for the terminal 1-yn-3-ol functional group in mediating cytotoxic activity.
Keywords: Porifera; ene-yne; HCT-116; cytotoxic activity; polyacetylene; pellynol

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Cite This Article

MDPI and ACS Style

Zhou, G.-X.; Molinski, T.F. Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity. Mar. Drugs 2003, 1, 46-53.

AMA Style

Zhou G-X, Molinski TF. Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity. Marine Drugs. 2003; 1(1):46-53.

Chicago/Turabian Style

Zhou, Guang-Xiong; Molinski, Tadeusz F. 2003. "Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity." Mar. Drugs 1, no. 1: 46-53.

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