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Mar. Drugs 2003, 1(1), 54-65; doi:10.3390/md101054
Article

Pseudopterosin Biosynthesis: Aromatization of the Diterpene Cyclase Product, Elisabethatriene

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Received: 15 October 2003; Accepted: 13 November 2003 / Published: 26 November 2003
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Putative precursors in pseudopterosin biosynthesis, the hydrocarbons isoelisabethatriene (10) and erogorgiaene (11), have been identified from an extract of Pseudopterogorgia elisabethae collected in the Florida Keys. Biosynthetic experiments designed to test the utilization of these compounds in pseudopterosin production revealed that erogorgiaene is transformed to pseudopterosins A-D. Together with our previous data, it is now apparent that early steps in pseudopterosin biosynthesis involve the cyclization of geranylgeranyl diphosphate to elisabethatriene followed by the dehydrogenation and aromatization to erogorgiaene.
Keywords: Biosynthesis; diterpene; elisabethatriene; Pseudopterogorgia elisabethae; pseudopterosin
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MDPI and ACS Style

Kohl, A.C.; Kerr, R.G. Pseudopterosin Biosynthesis: Aromatization of the Diterpene Cyclase Product, Elisabethatriene. Mar. Drugs 2003, 1, 54-65.

AMA Style

Kohl AC, Kerr RG. Pseudopterosin Biosynthesis: Aromatization of the Diterpene Cyclase Product, Elisabethatriene. Marine Drugs. 2003; 1(1):54-65.

Chicago/Turabian Style

Kohl, Amber C.; Kerr, Russell G. 2003. "Pseudopterosin Biosynthesis: Aromatization of the Diterpene Cyclase Product, Elisabethatriene." Mar. Drugs 1, no. 1: 54-65.

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