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Pharmaceuticals 2015, 8(3), 559-589; doi:10.3390/ph8030559

Ecology of Anti-Biofilm Agents II: Bacteriophage Exploitation and Biocontrol of Biofilm Bacteria

Department of Microbiology, The Ohio State University, 1680 University Dr., Mansfield, OH 44906, USA
Academic Editor: Dacheng Ren
Received: 19 July 2015 / Revised: 30 August 2015 / Accepted: 2 September 2015 / Published: 9 September 2015
(This article belongs to the Special Issue Microbial Biofilms)
View Full-Text   |   Download PDF [1893 KB, uploaded 9 September 2015]   |  

Abstract

Bacteriophages are the viruses of bacteria. In the guise of phage therapy they have been used for decades to successfully treat what are probable biofilm-containing chronic bacterial infections. More recently, phage treatment or biocontrol of biofilm bacteria has been brought back to the laboratory for more rigorous assessment as well as towards the use of phages to combat environmental biofilms, ones other than those directly associated with bacterial infections. Considered in a companion article is the inherent ecological utility of bacteriophages versus antibiotics as anti-biofilm agents. Discussed here is a model for phage ecological interaction with bacteria as they may occur across biofilm-containing ecosystems. Specifically, to the extent that individual bacterial types are not highly abundant within biofilm-containing environments, then phage exploitation of those bacteria may represent a “Feast-or-famine” existence in which infection of highly localized concentrations of phage-sensitive bacteria alternate with treacherous searches by the resulting phage progeny virions for new concentrations of phage-sensitive bacteria to infect. An updated synopsis of the literature concerning laboratory testing of phage use to combat bacterial biofilms is then provided along with tips on how “Ecologically” such phage-mediated biofilm control can be modified to more reliably achieve anti-biofilm efficacy. View Full-Text
Keywords: bacteriophage ecology; biocontrol; biofilms; biofilm control; biofilm eradication; ecology; phage ecology; phage therapy bacteriophage ecology; biocontrol; biofilms; biofilm control; biofilm eradication; ecology; phage ecology; phage therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Abedon, S.T. Ecology of Anti-Biofilm Agents II: Bacteriophage Exploitation and Biocontrol of Biofilm Bacteria. Pharmaceuticals 2015, 8, 559-589.

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