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Open AccessCommentary
Pharmaceuticals 2015, 8(3), 504-511; doi:10.3390/ph8030504

Prospects for Anti-Biofilm Pharmaceuticals

Center for Biofilm Engineering and Department of Chemical and Biological Engineering, 366 EPS Building, Montana State University, Bozeman, MT 59717, USA
Academic Editor: Dacheng Ren
Received: 1 July 2015 / Revised: 21 August 2015 / Accepted: 24 August 2015 / Published: 27 August 2015
(This article belongs to the Special Issue Microbial Biofilms)
View Full-Text   |   Download PDF [653 KB, uploaded 31 August 2015]

Abstract

This commentary highlights several avenues currently being pursued in research labs to the development of new anti-biofilm pharmaceuticals. There is a real need for alternative therapeutic modalities for treating the persistent infections that sometimes form on implanted medical devices or compromised niches within the body. Strategies being researched include discovering new antimicrobial agents that kill microorganisms in biofilms more effectively than do existing antibiotics, designing drugs that block microbial adhesion or interfere with intercellular communication, developing chemistries to disperse biofilms, and combining agents with different mechanisms of action. Though the need is great, the pathway to commercialization of new drugs is steep. One possible streamlined approach to navigating the regulatory approval process is to repurpose old drugs, a strategy that a few groups have shown can yield agents with anti-biofilm properties. View Full-Text
Keywords: biofilm; drug; antibiotic biofilm; drug; antibiotic
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Stewart, P.S. Prospects for Anti-Biofilm Pharmaceuticals. Pharmaceuticals 2015, 8, 504-511.

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