Next Article in Journal
Radiolabeled Cetuximab Conjugates for EGFR Targeted Cancer Diagnostics and Therapy
Next Article in Special Issue
“Specificity Determinants” Improve Therapeutic Indices of Two Antimicrobial Peptides Piscidin 1 and Dermaseptin S4 Against the Gram-negative Pathogens Acinetobacter baumannii and Pseudomonas aeruginosa
Previous Article in Journal / Special Issue
Lucifensins, the Insect Defensins of Biomedical Importance: The Story behind Maggot Therapy
Pharmaceuticals 2014, 7(3), 265-310; doi:10.3390/ph7030265

Antimicrobial Peptides from Fish

1 Department of Pediatrics and Graduate School of Biomedical Sciences, Rutgers New Jersey Medical School, Newark, NJ 07101, USA 2 Department of Oral Biology, University of Florida, Box 100424, Gainesville, FL 32610, USA
* Author to whom correspondence should be addressed.
Received: 15 January 2014 / Revised: 6 February 2014 / Accepted: 18 February 2014 / Published: 3 March 2014
View Full-Text   |   Download PDF [299 KB, uploaded 3 March 2014]   |   Browse Figures


Antimicrobial peptides (AMPs) are found widely distributed through Nature, and participate in the innate host defense of each species. Fish are a great source of these peptides, as they express all of the major classes of AMPs, including defensins, cathelicidins, hepcidins, histone-derived peptides, and a fish-specific class of the cecropin family, called piscidins. As with other species, the fish peptides exhibit broad-spectrum antimicrobial activity, killing both fish and human pathogens. They are also immunomodulatory, and their genes are highly responsive to microbes and innate immuno-stimulatory molecules. Recent research has demonstrated that some of the unique properties of fish peptides, including their ability to act even in very high salt concentrations, make them good potential targets for development as therapeutic antimicrobials. Further, the stimulation of their gene expression by exogenous factors could be useful in preventing pathogenic microbes in aquaculture.
Keywords: defensin; pleurocidin; cathelicidin; hepcidin; piscidin defensin; pleurocidin; cathelicidin; hepcidin; piscidin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Masso-Silva, J.A.; Diamond, G. Antimicrobial Peptides from Fish. Pharmaceuticals 2014, 7, 265-310.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert