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Pharmaceuticals 2013, 6(8), 988-1038; doi:10.3390/ph6080988

Personalizing Colon Cancer Therapeutics: Targeting Old and New Mechanisms of Action

Hematology/Oncology Division, Penn State Hershey Medical Center, Hershey, PA 17033, USA
* Author to whom correspondence should be addressed.
Received: 4 June 2013 / Revised: 30 July 2013 / Accepted: 16 August 2013 / Published: 21 August 2013
(This article belongs to the Special Issue Chemotherapeutic Agents)
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The use of pharmaceuticals for colon cancer treatment has been increasingly personalized, in part due to the development of new molecular tools. In this review, we discuss the old and new colon cancer chemotherapeutics, and the parameters that have been shown to be predictive of efficacy and safety of these chemotherapeutics. In addition, we discuss how alternate pharmaceuticals have been developed in light of a potential lack of response or resistance to a particular chemotherapeutic.
Keywords: colorectal cancer; personalized medicine; genetic polymorphisms colorectal cancer; personalized medicine; genetic polymorphisms
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kline, C.L.B.; El-Deiry, W.S. Personalizing Colon Cancer Therapeutics: Targeting Old and New Mechanisms of Action. Pharmaceuticals 2013, 6, 988-1038.

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