Next Article in Journal
Current Evidence of Chinese Herbal Constituents with Effects on NMDA Receptor Blockade
Next Article in Special Issue
Nanoparticles as Drug Delivery Systems in Cancer Medicine: Emphasis on RNAi-Containing Nanoliposomes
Previous Article in Journal
The Inhibition of Stat5 by a Peptide Aptamer Ligand Specific for the DNA Binding Domain Prevents Target Gene Transactivation and the Growth of Breast and Prostate Tumor Cells
Article Menu

Export Article

Open AccessReview
Pharmaceuticals 2013, 6(8), 988-1038; doi:10.3390/ph6080988

Personalizing Colon Cancer Therapeutics: Targeting Old and New Mechanisms of Action

Hematology/Oncology Division, Penn State Hershey Medical Center, Hershey, PA 17033, USA
*
Author to whom correspondence should be addressed.
Received: 4 June 2013 / Revised: 30 July 2013 / Accepted: 16 August 2013 / Published: 21 August 2013
(This article belongs to the Special Issue Chemotherapeutic Agents)
View Full-Text   |   Download PDF [1743 KB, uploaded 21 August 2013]   |  

Abstract

The use of pharmaceuticals for colon cancer treatment has been increasingly personalized, in part due to the development of new molecular tools. In this review, we discuss the old and new colon cancer chemotherapeutics, and the parameters that have been shown to be predictive of efficacy and safety of these chemotherapeutics. In addition, we discuss how alternate pharmaceuticals have been developed in light of a potential lack of response or resistance to a particular chemotherapeutic.
Keywords: colorectal cancer; personalized medicine; genetic polymorphisms colorectal cancer; personalized medicine; genetic polymorphisms
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kline, C.L.B.; El-Deiry, W.S. Personalizing Colon Cancer Therapeutics: Targeting Old and New Mechanisms of Action. Pharmaceuticals 2013, 6, 988-1038.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top