Pharmaceuticals 2013, 6(8), 1039-1054; doi:10.3390/ph6081039
Review

Current Evidence of Chinese Herbal Constituents with Effects on NMDA Receptor Blockade

Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong
* Authors to whom correspondence should be addressed.
Received: 29 May 2013; in revised form: 6 August 2013 / Accepted: 19 August 2013 / Published: 21 August 2013
(This article belongs to the Special Issue NMDA Receptor Antagonists for Treatment of CNS Disorders)
PDF Full-text Download PDF Full-Text [138 KB, uploaded 21 August 2013 15:32 CEST]
Abstract: NMDA receptor (NMDA-R) is an important molecular entity governing a wide range of functions in the central nervous system. For example, the NMDA-R is involved in memory and cognition, and impairment of both (as in Alzheimer’s Disease) is attributed to NMDA-mediated neurotoxicity. With greater understanding of the NMDA-R structure, antagonists with varying degrees of binding-site and subtype selectivity have been developed and put into clinical use. Discovery of target-specific Chinese herbs have also been made in parallel. This article provides an overview of the known active sites on the NMDA-R, followed by a discussion of the relevant herbs and their constituents. Experimental evidence supporting the inhibitory role of the herbal compounds on the NMDA-R is highlighted. For some of the compounds, potential research directions are also proposed to further elucidate the underlying mechanisms of the herbs. It is envisaged that future investigations based on the present data will allow more clinically relevant herbs to be identified.
Keywords: NMDA receptor; antagonist; herb; Chinese medicine

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Liang, W.; Lam, W.P.; Tang, H.C.; Leung, P.C.; Yew, D.T. Current Evidence of Chinese Herbal Constituents with Effects on NMDA Receptor Blockade. Pharmaceuticals 2013, 6, 1039-1054.

AMA Style

Liang W, Lam WP, Tang HC, Leung PC, Yew DT. Current Evidence of Chinese Herbal Constituents with Effects on NMDA Receptor Blockade. Pharmaceuticals. 2013; 6(8):1039-1054.

Chicago/Turabian Style

Liang, Willmann; Lam, Wai P.; Tang, Hong C.; Leung, Ping C.; Yew, David T. 2013. "Current Evidence of Chinese Herbal Constituents with Effects on NMDA Receptor Blockade." Pharmaceuticals 6, no. 8: 1039-1054.

Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert