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Pharmaceuticals 2013, 6(4), 500-509; doi:10.3390/ph6040500

The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists

Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, NY 14831, USA
* Author to whom correspondence should be addressed.
Received: 6 March 2013 / Revised: 20 March 2013 / Accepted: 1 April 2013 / Published: 8 April 2013
(This article belongs to the Special Issue GPCR Based Drug Discovery)
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Nearly 1% of all clinically used drugs are catecholics, a family of catechol-containing compounds. Using label-free dynamic mass redistribution and Tango β-arrestin translocation assays, we show that several catecholics, including benserazide, catechol, 3-methoxycatechol, pyrogallol, (+)-taxifolin and fenoldopam, display agonistic activity against GPR35.
Keywords: GPR35; benserazide; catechol; pyrogallol GPR35; benserazide; catechol; pyrogallol
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Deng, H.; Fang, Y. The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists. Pharmaceuticals 2013, 6, 500-509.

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