Next Article in Journal
Delivery of RNAi-Based Oligonucleotides by Electropermeabilization
Next Article in Special Issue
Targeting Platelet Thrombin Receptor Signaling to Prevent Thrombosis
Previous Article in Journal
NMDA Receptor Antagonists for Treatment of Depression
Previous Article in Special Issue
Pathophysiology of GPCR Homo- and Heterodimerization: Special Emphasis on Somatostatin Receptors
Pharmaceuticals 2013, 6(4), 500-509; doi:10.3390/ph6040500

The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists

Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, NY 14831, USA
* Author to whom correspondence should be addressed.
Received: 6 March 2013 / Revised: 20 March 2013 / Accepted: 1 April 2013 / Published: 8 April 2013
(This article belongs to the Special Issue GPCR Based Drug Discovery)
View Full-Text   |   Download PDF [939 KB, uploaded 8 April 2013]   |   Browse Figures


Nearly 1% of all clinically used drugs are catecholics, a family of catechol-containing compounds. Using label-free dynamic mass redistribution and Tango β-arrestin translocation assays, we show that several catecholics, including benserazide, catechol, 3-methoxycatechol, pyrogallol, (+)-taxifolin and fenoldopam, display agonistic activity against GPR35.
Keywords: GPR35; benserazide; catechol; pyrogallol GPR35; benserazide; catechol; pyrogallol
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Deng, H.; Fang, Y. The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists. Pharmaceuticals 2013, 6, 500-509.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert