Pharmaceuticals 2013, 6(4), 500-509; doi:10.3390/ph6040500
Article

The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists

Received: 6 March 2013; in revised form: 20 March 2013 / Accepted: 1 April 2013 / Published: 8 April 2013
(This article belongs to the Special Issue GPCR Based Drug Discovery)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Nearly 1% of all clinically used drugs are catecholics, a family of catechol-containing compounds. Using label-free dynamic mass redistribution and Tango β-arrestin translocation assays, we show that several catecholics, including benserazide, catechol, 3-methoxycatechol, pyrogallol, (+)-taxifolin and fenoldopam, display agonistic activity against GPR35.
Keywords: GPR35; benserazide; catechol; pyrogallol
PDF Full-text Download PDF Full-Text [939 KB, uploaded 8 April 2013 15:11 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Deng, H.; Fang, Y. The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists. Pharmaceuticals 2013, 6, 500-509.

AMA Style

Deng H, Fang Y. The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists. Pharmaceuticals. 2013; 6(4):500-509.

Chicago/Turabian Style

Deng, Huayun; Fang, Ye. 2013. "The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists." Pharmaceuticals 6, no. 4: 500-509.

Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert