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Pharmaceuticals 2013, 6(12), 1543-1575; doi:10.3390/ph6121543
Review

Antimicrobial Peptides

1,2
 and 1,2,3,4,*
Received: 22 October 2013; in revised form: 21 November 2013 / Accepted: 25 November 2013 / Published: 28 November 2013
(This article belongs to the Special Issue Peptide Drug Discovery and Development)
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Abstract: The rapid increase in drug-resistant infections has presented a serious challenge to antimicrobial therapies. The failure of the most potent antibiotics to kill “superbugs” emphasizes the urgent need to develop other control agents. Here we review the history and new development of antimicrobial peptides (AMPs), a growing class of natural and synthetic peptides with a wide spectrum of targets including viruses, bacteria, fungi, and parasites. We summarize the major types of AMPs, their modes of action, and the common mechanisms of AMP resistance. In addition, we discuss the principles for designing effective AMPs and the potential of using AMPs to control biofilms (multicellular structures of bacteria embedded in extracellular matrixes) and persister cells (dormant phenotypic variants of bacterial cells that are highly tolerant to antibiotics).
Keywords: antimicrobial peptide; biofilm; persister antimicrobial peptide; biofilm; persister
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bahar, A.A.; Ren, D. Antimicrobial Peptides. Pharmaceuticals 2013, 6, 1543-1575.

AMA Style

Bahar AA, Ren D. Antimicrobial Peptides. Pharmaceuticals. 2013; 6(12):1543-1575.

Chicago/Turabian Style

Bahar, Ali A.; Ren, Dacheng. 2013. "Antimicrobial Peptides." Pharmaceuticals 6, no. 12: 1543-1575.


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