Pharmaceuticals 2013, 6(12), 1543-1575; doi:10.3390/ph6121543
Review

Antimicrobial Peptides

1,2email and 1,2,3,4,* email
1 Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA 2 Syracuse Biomaterials Institute, Syracuse University, Syracuse, NY 13244, USA 3 Department of Civil and Environmental Engineering, Syracuse University, Syracuse, NY 13244, USA 4 Department of Biology, Syracuse University, Syracuse, NY 13244, USA
* Author to whom correspondence should be addressed.
Received: 22 October 2013; in revised form: 21 November 2013 / Accepted: 25 November 2013 / Published: 28 November 2013
(This article belongs to the Special Issue Peptide Drug Discovery and Development)
PDF Full-text Download PDF Full-Text [575 KB, uploaded 28 November 2013 15:44 CET]
Abstract: The rapid increase in drug-resistant infections has presented a serious challenge to antimicrobial therapies. The failure of the most potent antibiotics to kill “superbugs” emphasizes the urgent need to develop other control agents. Here we review the history and new development of antimicrobial peptides (AMPs), a growing class of natural and synthetic peptides with a wide spectrum of targets including viruses, bacteria, fungi, and parasites. We summarize the major types of AMPs, their modes of action, and the common mechanisms of AMP resistance. In addition, we discuss the principles for designing effective AMPs and the potential of using AMPs to control biofilms (multicellular structures of bacteria embedded in extracellular matrixes) and persister cells (dormant phenotypic variants of bacterial cells that are highly tolerant to antibiotics).
Keywords: antimicrobial peptide; biofilm; persister

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Bahar, A.A.; Ren, D. Antimicrobial Peptides. Pharmaceuticals 2013, 6, 1543-1575.

AMA Style

Bahar AA, Ren D. Antimicrobial Peptides. Pharmaceuticals. 2013; 6(12):1543-1575.

Chicago/Turabian Style

Bahar, Ali A.; Ren, Dacheng. 2013. "Antimicrobial Peptides." Pharmaceuticals 6, no. 12: 1543-1575.

Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert