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Aptamer-Based Therapeutics: New Approaches to Combat Human Viral Diseases
Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, 1500 East Duarte Rd, Duarte, CA 91010, USA
Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, 1500 East Duarte Rd, Duarte, CA 91010, USA
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 17 October 2013; in revised form: 12 November 2013 / Accepted: 15 November 2013 / Published: 25 November 2013
Abstract: Viruses replicate inside the cells of an organism and continuously evolve to contend with an ever-changing environment. Many life-threatening diseases, such as AIDS, SARS, hepatitis and some cancers, are caused by viruses. Because viruses have small genome sizes and high mutability, there is currently a lack of and an urgent need for effective treatment for many viral pathogens. One approach that has recently received much attention is aptamer-based therapeutics. Aptamer technology has high target specificity and versatility, i.e., any viral proteins could potentially be targeted. Consequently, new aptamer-based therapeutics have the potential to lead a revolution in the development of anti-infective drugs. Additionally, aptamers can potentially bind any targets and any pathogen that is theoretically amenable to rapid targeting, making aptamers invaluable tools for treating a wide range of diseases. This review will provide a broad, comprehensive overview of viral therapies that use aptamers. The aptamer selection process will be described, followed by an explanation of the potential for treating virus infection by aptamers. Recent progress and prospective use of aptamers against a large variety of human viruses, such as HIV-1, HCV, HBV, SCoV, Rabies virus, HPV, HSV and influenza virus, with particular focus on clinical development of aptamers will also be described. Finally, we will discuss the challenges of advancing antiviral aptamer therapeutics and prospects for future success.
Keywords: SELEX; aptamers; virus; HIV-1; RNA nanotechnology
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Shum, K.-T.; Zhou, J.; Rossi, J.J. Aptamer-Based Therapeutics: New Approaches to Combat Human Viral Diseases. Pharmaceuticals 2013, 6, 1507-1542.
Shum K-T, Zhou J, Rossi JJ. Aptamer-Based Therapeutics: New Approaches to Combat Human Viral Diseases. Pharmaceuticals. 2013; 6(12):1507-1542.
Shum, Ka-To; Zhou, Jiehua; Rossi, John J. 2013. "Aptamer-Based Therapeutics: New Approaches to Combat Human Viral Diseases." Pharmaceuticals 6, no. 12: 1507-1542.