Pharmaceuticals 2013, 6(10), 1195-1220; doi:10.3390/ph6101195
Review

MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression

Received: 8 August 2013; in revised form: 17 September 2013 / Accepted: 17 September 2013 / Published: 30 September 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The discovery of small RNA molecules with the capacity to regulate messenger RNA (mRNA) stability and translation (and consequently protein synthesis) has revealed an additional level of post-transcriptional gene control. MicroRNAs (miRNAs), an evolutionarily conserved class of small noncoding RNAs that regulate gene expression post-transcriptionally by base pairing to complementary sequences in the 3' untranslated regions of target mRNAs, are part of this modulatory RNA network playing a pivotal role in cell fate. Functional studies indicate that miRNAs are involved in the regulation of almost every biological pathway, while changes in miRNA expression are associated with several human pathologies, including cancer. By targeting oncogenes and tumor suppressors, miRNAs have the ability to modulate key cellular processes that define the cell phenotype, making them highly promising therapeutic targets. Over the last few years, miRNA-based anti-cancer therapeutic approaches have been exploited, either alone or in combination with standard targeted therapies, aiming at enhancing tumor cell killing and, ideally, promoting tumor regression and disease remission. Here we provide an overview on the involvement of miRNAs in cancer pathology, emphasizing the mechanisms of miRNA regulation. Strategies for modulating miRNA expression are presented and illustrated with representative examples of their application in a therapeutic context.
Keywords: microRNA (miRNA); anti-miRNA oligonucleotides; miRNA mimics; cancer therapy; viral and non-viral carriers
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MDPI and ACS Style

Costa, P.M.; Pedroso de Lima, M.C. MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression. Pharmaceuticals 2013, 6, 1195-1220.

AMA Style

Costa PM, Pedroso de Lima MC. MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression. Pharmaceuticals. 2013; 6(10):1195-1220.

Chicago/Turabian Style

Costa, Pedro M.; Pedroso de Lima, Maria C. 2013. "MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression." Pharmaceuticals 6, no. 10: 1195-1220.

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