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• Ghazi-Moghadam, K
• Inançlı, H
• Bazazy, N
• Plinkert, P
• Efferth, T
• Sertel, S
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• Ghazi-Moghadam, K
• Inançlı, H
• Bazazy, N
• Plinkert, P
• Efferth, T
• Sertel, S
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• Ghazi-Moghadam, K
• Inançlı, H
• Bazazy, N
• Plinkert, P
• Efferth, T
• Sertel, S

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Pharmaceuticals 2012, 5(8), 853-874; doi:10.3390/ph5080853

Review

Phytomedicine in Otorhinolaryngology and Pulmonology: Clinical Trials with Herbal Remedies

Koosha Ghazi-Moghadam ^1,2 , Hasan Mete Inançlı ³ , Nazanin Bazazy ¹ , Peter K. Plinkert ¹ , Thomas Efferth ⁴  and Serkan Sertel ^1,2,4,*

¹ Department of Otorhinolaryngology, Head & Neck Surgery, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany ² Molecular Mechanisms of Head and Neck T—A102, Division Signal Transduction and Growth Control, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany ³ Department of Otorhinolaryngology, Near East University Hospital, 922022 Lefkosa, Turkish Republic of Northern Cyprus ⁴ Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudingerweg 5, 55099 Mainz, Germany

* Author to whom correspondence should be addressed.

Received: 5 July 2012 / Accepted: 8 August 2012 / Published: 20 August 2012

(This article belongs to the Special Issue Phytomedicine)

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Abstract: Phytomedicine has become an important alternative treatment option for patients in the Western world, as they seek to be treated in a holistic and natural way after an unsatisfactory response to conventional drugs. Ever since herbal remedies have been introduced in the Western world, clinicians have raised concerns over their efficacy and possible side-effects. A PubMed (Medline) search was performed covering the last five years (01/07–04/12) and including 55 prospective clinical randomized control trials in the medical specialities Otorhinolaryngology and Pulmonology. In this review, we present evidence-based clinical data with herbal remedies and try to enlighten the question of efficacy and reliability of phytomedicine.

Keywords: phytomedicine; herbal remedy; clinical trial; evidence-based; otorhinolaryngology; pulmonology

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