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• Arima, H
• Motoyama, K
• Higashi, T
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• Motoyama, K
• Higashi, T
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• Motoyama, K
• Higashi, T

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Pharmaceuticals 2012, 5(1), 61-78; doi:10.3390/ph5010061

Review

Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA

Hidetoshi Arima* , Keiichi Motoyama and Taishi Higashi

Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan

* Author to whom correspondence should be addressed.

Received: 31 October 2011; in revised form: 20 December 2011 / Accepted: 21 December 2011 / Published: 30 December 2011

(This article belongs to the Special Issue RNAi-Based Therapeutics)

Download PDF Full-Text [572 KB, uploaded 30 December 2011 10:44 CET]

Abstract: Cyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM) starburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently, small interfering RNA (siRNA) complex with β-CyD-containing polycations (CDP) having adamantine-PEG or adamantine-PEG-transferrin underwent a phase I study for treatment of solid tumors. Multifunctional dendrimers can be used for a wide range of biomedical applications, including the interaction and intracellular delivery of DNA and RNA. The present review will address the latest developments in dendrimer conjugates with cyclodextrins for siRNA delivery including the novel sustained release system.

Keywords: cyclodextrin; polyamidoamine dendrimer; conjugate; siRNA delivery; multifunction

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