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Pharmaceuticals 2012, 5(1), 61-78; doi:10.3390/ph5010061
Review

Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA

* ,  and
Received: 31 October 2011; in revised form: 20 December 2011 / Accepted: 21 December 2011 / Published: 30 December 2011
(This article belongs to the Special Issue RNAi-Based Therapeutics)
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Abstract: Cyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM) starburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently, small interfering RNA (siRNA) complex with β-CyD-containing polycations (CDP) having adamantine-PEG or adamantine-PEG-transferrin underwent a phase I study for treatment of solid tumors. Multifunctional dendrimers can be used for a wide range of biomedical applications, including the interaction and intracellular delivery of DNA and RNA. The present review will address the latest developments in dendrimer conjugates with cyclodextrins for siRNA delivery including the novel sustained release system.
Keywords: cyclodextrin; polyamidoamine dendrimer; conjugate; siRNA delivery; multifunction cyclodextrin; polyamidoamine dendrimer; conjugate; siRNA delivery; multifunction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Arima, H.; Motoyama, K.; Higashi, T. Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA. Pharmaceuticals 2012, 5, 61-78.

AMA Style

Arima H, Motoyama K, Higashi T. Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA. Pharmaceuticals. 2012; 5(1):61-78.

Chicago/Turabian Style

Arima, Hidetoshi; Motoyama, Keiichi; Higashi, Taishi. 2012. "Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA." Pharmaceuticals 5, no. 1: 61-78.


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