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Pharmaceuticals 2012, 5(1), 61-78; doi:10.3390/ph5010061

Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA

Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan
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Author to whom correspondence should be addressed.
Received: 31 October 2011 / Revised: 20 December 2011 / Accepted: 21 December 2011 / Published: 30 December 2011
(This article belongs to the Special Issue RNAi-Based Therapeutics)
View Full-Text   |   Download PDF [572 KB, uploaded 30 December 2011]   |  

Abstract

Cyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM) starburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently, small interfering RNA (siRNA) complex with β-CyD-containing polycations (CDP) having adamantine-PEG or adamantine-PEG-transferrin underwent a phase I study for treatment of solid tumors. Multifunctional dendrimers can be used for a wide range of biomedical applications, including the interaction and intracellular delivery of DNA and RNA. The present review will address the latest developments in dendrimer conjugates with cyclodextrins for siRNA delivery including the novel sustained release system. View Full-Text
Keywords: cyclodextrin; polyamidoamine dendrimer; conjugate; siRNA delivery; multifunction cyclodextrin; polyamidoamine dendrimer; conjugate; siRNA delivery; multifunction
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Arima, H.; Motoyama, K.; Higashi, T. Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA. Pharmaceuticals 2012, 5, 61-78.

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