Next Article in Journal
Mitochondrial Dysfunction and Oxidative Stress in Asthma: Implications for Mitochondria-Targeted Antioxidant Therapeutics
Next Article in Special Issue
RNA Detection in Live Bacterial Cells Using Fluorescent Protein Complementation Triggered by Interaction of Two RNA Aptamers with Two RNA-Binding Peptides
Previous Article in Journal
Neuroactive Multifunctional Tacrine Congeners with Cholinesterase, Anti-Amyloid Aggregation and Neuroprotective Properties
Pharmaceuticals 2011, 4(2), 419-428; doi:10.3390/ph4020419

Metallo-β-Lactamases and Aptamer-Based Inhibition

, ,  and *
Department of Chemistry and Biochemistry and the Institute of Biomedical Studies, Baylor University, Waco, TX 76798, USA
* Author to whom correspondence should be addressed.
Received: 14 January 2011 / Revised: 8 February 2011 / Accepted: 16 February 2011 / Published: 18 February 2011
(This article belongs to the Special Issue Aptamer-Based Therapeutics)
View Full-Text   |   Download PDF [358 KB, uploaded 18 February 2011]   |   Browse Figures


An evolution of antibiotic-resistant bacteria has resulted in the need for new antibiotics. β-Lactam based drugs are the most predominantly prescribed antibiotics to combat bacterial infections; however, production of β-lactamases, which catalyze the hydrolysis of the β-lactam bond of this class of antibiotics, by pathogenic bacteria such as Bacillus cereus, are rendering them useless. Some inhibitors of β-lactamases have been found, but there are no inhibitors against a class of β-lactamases known as metallo-β-lactamases, and it has been reported that the number of bacteria that produce metallo-β-lactamases is on the rise. Finding inhibitors of metallo-β-lactamases is thus an urgent necessity. One way to approach the problem is by employing the combinatorial method SELEX. The SELEX method is significant in discovering and producing new classes of inhibitors, as well as providing insight into the development of these inhibitors and paves the way for future aptamer applications that further novel drug discovery.
Keywords: metallo-β-lactamase; aptamer; SELEX; inhibitor; Bacillus cereus metallo-β-lactamase; aptamer; SELEX; inhibitor; Bacillus cereus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Schlesinger, S.R.; Lahousse, M.J.; Foster, T.O.; Kim, S.-K. Metallo-β-Lactamases and Aptamer-Based Inhibition. Pharmaceuticals 2011, 4, 419-428.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert