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Cardiorenal Effects of Kappa Opioid Peptides During Ontogeny
Department of Physiology & Pharmacology/Paediatrics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, T2N 4N1, Canada
* Author to whom correspondence should be addressed.
Received: 9 December 2010; in revised form: 30 December 2010 / Accepted: 7 January 2011 / Published: 11 January 2011
(This article belongs to the Special Issue Opioids
Abstract: This review focuses on the physiological roles for kappa opioid receptors (KORs) in adult animals and humans, as well as in the developing newborn animal. Our recent findings have provided new information that under physiological conditions in conscious newborn animals, activation of KORs with the selective agonist, U-50488H, results in an aquaresis, as previously observed in adult animals and humans. In addition, we have shown in conscious lambs that KORs modulate systemic and renal haemodynamics as well as the arterial baroreflex control of heart rate, providing a previously unidentified role for KORs.
Keywords: kappa opioid peptides; KORs; newborn; physiology
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Smith, F.G.; Qi, W. Cardiorenal Effects of Kappa Opioid Peptides During Ontogeny. Pharmaceuticals 2011, 4, 154-168.
Smith FG, Qi W. Cardiorenal Effects of Kappa Opioid Peptides During Ontogeny. Pharmaceuticals. 2011; 4(1):154-168.
Smith, Francine G.; Qi, Wei. 2011. "Cardiorenal Effects of Kappa Opioid Peptides During Ontogeny." Pharmaceuticals 4, no. 1: 154-168.