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Tissue Engineering of Cartilage; Can Cannabinoids Help?
Trinity College Institute of Neuroscience and Department of Physiology, School of Medicine, University of Dublin, Trinity College, Dublin 2, Ireland
Trinity Centre for Bio-Engineering, School of Engineering, University of Dublin, Trinity College, Dublin 2, Ireland
* Author to whom correspondence should be addressed.
Received: 15 July 2010; in revised form: 30 August 2010 / Accepted: 3 September 2010 / Published: 6 September 2010
Abstract: This review discusses the role of the cannabinoid system in cartilage tissue and endeavors to establish if targeting the cannabinoid system has potential in mesenchymal stem cell based tissue-engineered cartilage repair strategies. The review discusses the potential of cannabinoids to protect against the degradation of cartilage in inflamed arthritic joints and the influence of cannabinoids on the chondrocyte precursors, mesenchymal stem cells (MSCs). We provide experimental evidence to show that activation of the cannabinoid system enhances the survival, migration and chondrogenic differentiation of MSCs, which are three major tenets behind the success of a cell-based tissue-engineered cartilage repair strategy. These findings highlight the potential for cannabinoids to provide a dual function by acting as anti-inflammatory agents as well as regulators of MSC biology in order to enhance tissue engineering strategies aimed at cartilage repair.
Keywords: phytocannabinoids; cannabinoid receptors; mesenchymal stem cells; osteoarthritis; cartilage
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MDPI and ACS Style
Gowran, A.; McKayed, K.; Kanichai, M.; White, C.; Hammadi, N.; Campbell, V. Tissue Engineering of Cartilage; Can Cannabinoids Help? Pharmaceuticals 2010, 3, 2970-2985.
Gowran A, McKayed K, Kanichai M, White C, Hammadi N, Campbell V. Tissue Engineering of Cartilage; Can Cannabinoids Help? Pharmaceuticals. 2010; 3(9):2970-2985.
Gowran, Aoife; McKayed, Katey; Kanichai, Manoj; White, Cillian; Hammadi, Nissrin; Campbell, Veronica. 2010. "Tissue Engineering of Cartilage; Can Cannabinoids Help?" Pharmaceuticals 3, no. 9: 2970-2985.