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Pharmaceuticals 2010, 3(9), 2956-2969; doi:10.3390/ph3092956
Review

The Art of Managing Conversions between Antiepileptic Drugs: Maximizing Patient Tolerability and Quality of Life

Received: 29 July 2010; in revised form: 12 August 2010 / Accepted: 2 September 2010 / Published: 6 September 2010
(This article belongs to the Special Issue Antiepileptic Drugs)
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Abstract: Conversion between anti-epilectic drugs (AEDs) is frequently necessary in epilepsy care, exposing patients to a risk of incurring adverse effects and reduced quality of life. Little practical guidance is available to practitioners to guide conversions between AED monotherapies, or in adding a new adjunctive AED into a polytherapy regimen. This article reviews the impact of adverse effects of AEDs on quality of life in epilepsy patients, then reviews several important patient-related factors such as age, gender, medical and psychiatric co-morbidities, and co-medications that must be considered when selecting AEDs and ensuring tolerable and safe AED conversions. Practical strategies for transitional polytherapy AED conversion are then considered in different commonly encountered clinical scenarios in newly diagnosed and refractory epilepsy care, including inadequate seizure control, intolerable adverse effects, or idiosyncratic safety hazards. Successful conversion between AEDs requires regular monitoring for patient-reported adverse effects and appropriately reactive adjustment of AED therapy to maximize patient quality of life.
Keywords: epilepsy; antiepileptic drugs; conversion; monotherapy; polytherapy; quality of life epilepsy; antiepileptic drugs; conversion; monotherapy; polytherapy; quality of life
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Louis, E.K.S. The Art of Managing Conversions between Antiepileptic Drugs: Maximizing Patient Tolerability and Quality of Life. Pharmaceuticals 2010, 3, 2956-2969.

AMA Style

Louis EKS. The Art of Managing Conversions between Antiepileptic Drugs: Maximizing Patient Tolerability and Quality of Life. Pharmaceuticals. 2010; 3(9):2956-2969.

Chicago/Turabian Style

Louis, Erik K. St. 2010. "The Art of Managing Conversions between Antiepileptic Drugs: Maximizing Patient Tolerability and Quality of Life." Pharmaceuticals 3, no. 9: 2956-2969.


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