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Pharmaceuticals 2010, 3(8), 2416-2425; doi:10.3390/ph3082416

Synthesis and Antimicrobial Activity of Some New Quinoxaline Derivatives

1,* , 1
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Institute of Foreign Trade and Management, Moradabad - 244001, India 2 School of Pharmaceutical Sciences, Shobhit University, Meerut, India
* Author to whom correspondence should be addressed.
Received: 25 May 2010 / Revised: 13 July 2010 / Accepted: 16 July 2010 / Published: 30 July 2010
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2-Chloro-3-methylquinoxaline was selected as a nucleus around which various molecular transformations were performed to obtain new compounds expected to possess optimized antimicrobial activity. As very little work regarding attachment of ether linkages replacing chlorine at C-2 has been reported, it was thought worthwhile to synthesize various quinoxaline derivatives by replacing the C2 chlorine with an ether linkage attached to a benzene ring possessing an aldehyde or a free amino group which can be further reacted with aromatic amines and aromatic aldehydes, respectively, to yield new Schiff bases containing quinoxaline moieties. Thus the compounds 4-(2-methylquinoxalinyloxy) benzaldehyde (4), 2-[4-(substituted-benziminomethyl)-phenoxy]-3-methyl quinoxalines 5a–e, 4-(2-methyl-quinoxaline-3-yloxy)benzamine (6) and 4-(2-methylquinoxalin-3-yloxy)-N-substituted benzylidine benzamines 7a–e were synthesized and tested for their antimicrobial activity. The structures of the compounds were confirmed on the basis of their elemental and spectral data.
Keywords: quinoxalines; benzamine; benzaldehyde; antimicrobial activity quinoxalines; benzamine; benzaldehyde; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Singh, D.P.; Deivedi, S.K.; Hashim, S.R.; Singhal, R.G. Synthesis and Antimicrobial Activity of Some New Quinoxaline Derivatives. Pharmaceuticals 2010, 3, 2416-2425.

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