Pharmaceuticals 2010, 3(8), 2416-2425; doi:10.3390/ph3082416

Synthesis and Antimicrobial Activity of Some New Quinoxaline Derivatives

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Received: 25 May 2010; in revised form: 13 July 2010 / Accepted: 16 July 2010 / Published: 30 July 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: 2-Chloro-3-methylquinoxaline was selected as a nucleus around which various molecular transformations were performed to obtain new compounds expected to possess optimized antimicrobial activity. As very little work regarding attachment of ether linkages replacing chlorine at C-2 has been reported, it was thought worthwhile to synthesize various quinoxaline derivatives by replacing the C2 chlorine with an ether linkage attached to a benzene ring possessing an aldehyde or a free amino group which can be further reacted with aromatic amines and aromatic aldehydes, respectively, to yield new Schiff bases containing quinoxaline moieties. Thus the compounds 4-(2-methylquinoxalinyloxy) benzaldehyde (4), 2-[4-(substituted-benziminomethyl)-phenoxy]-3-methyl quinoxalines 5a–e, 4-(2-methyl-quinoxaline-3-yloxy)benzamine (6) and 4-(2-methylquinoxalin-3-yloxy)-N-substituted benzylidine benzamines 7a–e were synthesized and tested for their antimicrobial activity. The structures of the compounds were confirmed on the basis of their elemental and spectral data.
Keywords: quinoxalines; benzamine; benzaldehyde; antimicrobial activity
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MDPI and ACS Style

Singh, D.P.; Deivedi, S.K.; Hashim, S.R.; Singhal, R.G. Synthesis and Antimicrobial Activity of Some New Quinoxaline Derivatives. Pharmaceuticals 2010, 3, 2416-2425.

AMA Style

Singh DP, Deivedi SK, Hashim SR, Singhal RG. Synthesis and Antimicrobial Activity of Some New Quinoxaline Derivatives. Pharmaceuticals. 2010; 3(8):2416-2425.

Chicago/Turabian Style

Singh, Dharmchand Prasad; Deivedi, Sanjay Kumar; Hashim, Syed Riaz; Singhal, Ram Gopal. 2010. "Synthesis and Antimicrobial Activity of Some New Quinoxaline Derivatives." Pharmaceuticals 3, no. 8: 2416-2425.

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