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Pharmaceuticals 2010, 3(7), 2291-2321; doi:10.3390/ph3072291
Review

Nonsteroidal Anti-Inflammatory Drugs and the Kidney

Received: 30 June 2010; in revised form: 16 July 2010 / Accepted: 20 July 2010 / Published: 21 July 2010
(This article belongs to the collection Non-Steroidal Anti-Inflammatory Drugs)
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Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the isoenzymes COX-1 and COX-2 of cyclooxygenase (COX). Renal side effects (e.g., kidney function, fluid and urinary electrolyte excretion) vary with the extent of COX-2-COX-1 selectivity and the administered dose of these compounds. While young healthy subjects will rarely experience adverse renal effects with the use of NSAIDs, elderly patients and those with co-morbibity (e.g., congestive heart failure, liver cirrhosis or chronic kidney disease) and drug combinations (e.g., renin-angiotensin blockers, diuretics plus NSAIDs) may develop acute renal failure. This review summarizes our present knowledge how traditional NSAIDs and selective COX-2 inhibitors may affect the kidney under various experimental and clinical conditions, and how these drugs may influence renal inflammation, water transport, sodium and potassium balance and how renal dysfunction or hypertension
may result.
Keywords: non-steroidal anti-inflammatory drugs; cyclooxygenase; celecoxib; acute renal failure; chronic kidney disease non-steroidal anti-inflammatory drugs; cyclooxygenase; celecoxib; acute renal failure; chronic kidney disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hörl, W.H. Nonsteroidal Anti-Inflammatory Drugs and the Kidney. Pharmaceuticals 2010, 3, 2291-2321.

AMA Style

Hörl WH. Nonsteroidal Anti-Inflammatory Drugs and the Kidney. Pharmaceuticals. 2010; 3(7):2291-2321.

Chicago/Turabian Style

Hörl, Walter H. 2010. "Nonsteroidal Anti-Inflammatory Drugs and the Kidney." Pharmaceuticals 3, no. 7: 2291-2321.


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