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Nonsteroidal Anti-Inflammatory Drugs and the Kidney
Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria
Received: 30 June 2010; in revised form: 16 July 2010 / Accepted: 20 July 2010 / Published: 21 July 2010
Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the isoenzymes COX-1 and COX-2 of cyclooxygenase (COX). Renal side effects (e.g., kidney function, fluid and urinary electrolyte excretion) vary with the extent of COX-2-COX-1 selectivity and the administered dose of these compounds. While young healthy subjects will rarely experience adverse renal effects with the use of NSAIDs, elderly patients and those with co-morbibity (e.g., congestive heart failure, liver cirrhosis or chronic kidney disease) and drug combinations (e.g., renin-angiotensin blockers, diuretics plus NSAIDs) may develop acute renal failure. This review summarizes our present knowledge how traditional NSAIDs and selective COX-2 inhibitors may affect the kidney under various experimental and clinical conditions, and how these drugs may influence renal inflammation, water transport, sodium and potassium balance and how renal dysfunction or hypertension
Keywords: non-steroidal anti-inflammatory drugs; cyclooxygenase; celecoxib; acute renal failure; chronic kidney disease
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Cite This Article
MDPI and ACS Style
Hörl, W.H. Nonsteroidal Anti-Inflammatory Drugs and the Kidney. Pharmaceuticals 2010, 3, 2291-2321.
Hörl WH. Nonsteroidal Anti-Inflammatory Drugs and the Kidney. Pharmaceuticals. 2010; 3(7):2291-2321.
Hörl, Walter H. 2010. "Nonsteroidal Anti-Inflammatory Drugs and the Kidney." Pharmaceuticals 3, no. 7: 2291-2321.