- freely available
Nonsteroidal Anti-Inflammatory Drugs and the Kidney
AbstractNon-steroidal anti-inflammatory drugs (NSAIDs) inhibit the isoenzymes COX-1 and COX-2 of cyclooxygenase (COX). Renal side effects (e.g., kidney function, fluid and urinary electrolyte excretion) vary with the extent of COX-2-COX-1 selectivity and the administered dose of these compounds. While young healthy subjects will rarely experience adverse renal effects with the use of NSAIDs, elderly patients and those with co-morbibity (e.g., congestive heart failure, liver cirrhosis or chronic kidney disease) and drug combinations (e.g., renin-angiotensin blockers, diuretics plus NSAIDs) may develop acute renal failure. This review summarizes our present knowledge how traditional NSAIDs and selective COX-2 inhibitors may affect the kidney under various experimental and clinical conditions, and how these drugs may influence renal inflammation, water transport, sodium and potassium balance and how renal dysfunction or hypertension
Share & Cite This Article
Hörl, W.H. Nonsteroidal Anti-Inflammatory Drugs and the Kidney. Pharmaceuticals 2010, 3, 2291-2321.View more citation formats
Hörl WH. Nonsteroidal Anti-Inflammatory Drugs and the Kidney. Pharmaceuticals. 2010; 3(7):2291-2321.Chicago/Turabian Style
Hörl, Walter H. 2010. "Nonsteroidal Anti-Inflammatory Drugs and the Kidney." Pharmaceuticals 3, no. 7: 2291-2321.