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Commentary of Pharmaceuticals 2010, 3(1), 146-157.

Open AccessCommentary
Pharmaceuticals 2010, 3(6), 1887-1891; doi:10.3390/ph3061887

In Response to: ‘Impact of Glycosylation on Effector Functions of Therapeutic IgG’ (Pharmaceuticals 2010, 3, 146–157)

1
Meridian Biopharmaceuticals GmbH, Brunnerstrasse 59, 1230 Wien, Austria
2
Vela Pharmazeutische Entwicklung und Laboranalytik GmbH, Brunnerstrasse 59, 1230 Wien, Austria
3
Virologik GmbH, Henkestrasse 91, 91052 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Received: 29 April 2010 / Revised: 31 May 2010 / Accepted: 9 June 2010 / Published: 10 June 2010
(This article belongs to the Special Issue Monoclonal Antibody)
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Abstract

To complete the review article by Abes and colleagues (Pharmaceuticals 2010, 3, 146–157) which provides a good overview on recently developed approaches for generation of glyco-modified antibodies and the impact of glyco-modification of antibodies on their effector functions, important information should be added, namely that — besides the Glycart and the Biowa approach to generate de-fucosylated antibodies — innovative, moss derived methods have been shown to generate glyco-modified antibodies with improved effector function profile.
Keywords: therapeutic antibodies; glyco-modified IgG; ADCC; CDC; Fc -γRIII therapeutic antibodies; glyco-modified IgG; ADCC; CDC; Fc -γRIII
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Nechansky, A.; Koller, I.; Kircheis, R. In Response to: ‘Impact of Glycosylation on Effector Functions of Therapeutic IgG’ (Pharmaceuticals 2010, 3, 146–157). Pharmaceuticals 2010, 3, 1887-1891.

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