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Pharmaceuticals 2010, 3(6), 1873-1886; doi:10.3390/ph3061873

Cannabinoids and Viral Infections

Department of Biology, Center for Neural Science, NYU Cancer Institute and Department of Microbiology, New York University, 100 Washington Square East, New York, NY, 10003, USA
Received: 21 May 2010 / Revised: 28 May 2010 / Accepted: 9 June 2010 / Published: 9 June 2010
(This article belongs to the Special Issue Cannabinoids)
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Abstract

Exogenous cannabinoids or receptor antagonists may influence many cellular and systemic host responses. The anti-inflammatory activity of cannabinoids may compromise host inflammatory responses to acute viral infections, but may be beneficial in persistent infections. In neurons, where innate antiviral/pro-resolution responses include the activation of NOS-1, inhibition of Ca2+ activity by cannabinoids, increased viral replication and disease. This review examines the effect(s) of cannabinoids and their antagonists in viral infections. View Full-Text
Keywords: pathogens; virus infection; immunomodulation; inflammation pathogens; virus infection; immunomodulation; inflammation
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Reiss, C.S. Cannabinoids and Viral Infections. Pharmaceuticals 2010, 3, 1873-1886.

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