Pharmaceuticals 2010, 3(5), 1550-1560; doi:10.3390/ph3051550
Review

The Role of Non-Steroidal Anti-Inflammatory Drugs in the Chemoprevention of Breast Cancer

Received: 31 March 2010; in revised form: 26 April 2010 / Accepted: 10 May 2010 / Published: 17 May 2010
(This article belongs to the collection Non-Steroidal Anti-Inflammatory Drugs)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Epidemiological evidence suggests that non-steroidal anti-inflammatory drugs (NSAIDs) which act as cyclooxygenase (COX-2) inhibitors may reduce breast cancer incidence by up to 20%. These agents are often taken for pain relief by older women with osteoarthritis. Age is the major risk factor for breast cancer in women with 50% cases being diagnosed in those aged >65 years. NSAIDs reduce serum estradiol by 17% in post-menopausal women and since most of these who develop breast cancers have estrogen receptor positive tumours; this suggests a possible preventative role. Careful use of these agents could provide a strategy for both relief of symptoms of osteoarthritis and also breast cancer prevention. Instead of conducting a randomised trial, proof of efficacy could be from an adequately powered cohort study within the breast screening programme.
Keywords: non-steroidal anti-inflammatory drugs; breast cancer; chemoprevention
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MDPI and ACS Style

Horn, S.L.; Fentiman, I.S. The Role of Non-Steroidal Anti-Inflammatory Drugs in the Chemoprevention of Breast Cancer. Pharmaceuticals 2010, 3, 1550-1560.

AMA Style

Horn SL, Fentiman IS. The Role of Non-Steroidal Anti-Inflammatory Drugs in the Chemoprevention of Breast Cancer. Pharmaceuticals. 2010; 3(5):1550-1560.

Chicago/Turabian Style

Horn, Sarah L.; Fentiman, Ian S. 2010. "The Role of Non-Steroidal Anti-Inflammatory Drugs in the Chemoprevention of Breast Cancer." Pharmaceuticals 3, no. 5: 1550-1560.

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