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Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Progress in Small Molecule Drug Development
Pharmaceuticals 2010, 3(5), 1550-1560; doi:10.3390/ph3051550
Review

The Role of Non-Steroidal Anti-Inflammatory Drugs in the Chemoprevention of Breast Cancer

*  and
Hedley Atkins Breast Unit, Guy’s Hospital, London SE1 9RT, UK
* Author to whom correspondence should be addressed.
Received: 31 March 2010 / Revised: 26 April 2010 / Accepted: 10 May 2010 / Published: 17 May 2010
(This article belongs to the collection Non-Steroidal Anti-Inflammatory Drugs)
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Abstract

Epidemiological evidence suggests that non-steroidal anti-inflammatory drugs (NSAIDs) which act as cyclooxygenase (COX-2) inhibitors may reduce breast cancer incidence by up to 20%. These agents are often taken for pain relief by older women with osteoarthritis. Age is the major risk factor for breast cancer in women with 50% cases being diagnosed in those aged >65 years. NSAIDs reduce serum estradiol by 17% in post-menopausal women and since most of these who develop breast cancers have estrogen receptor positive tumours; this suggests a possible preventative role. Careful use of these agents could provide a strategy for both relief of symptoms of osteoarthritis and also breast cancer prevention. Instead of conducting a randomised trial, proof of efficacy could be from an adequately powered cohort study within the breast screening programme.
Keywords: non-steroidal anti-inflammatory drugs; breast cancer; chemoprevention non-steroidal anti-inflammatory drugs; breast cancer; chemoprevention
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Horn, S.L.; Fentiman, I.S. The Role of Non-Steroidal Anti-Inflammatory Drugs in the Chemoprevention of Breast Cancer. Pharmaceuticals 2010, 3, 1550-1560.

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