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Pharmaceuticals 2010, 3(2), 433-440; doi:10.3390/ph3020433
The Vasohibin Family
Received: 13 January 2010; in revised form: 23 January 2010 / Accepted: 3 February 2010 / Published: 5 February 2010
(This article belongs to the Special Issue Angiogenesis Inhibitors)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Angiogenesis is regulated by the local balance between angiogenesis stimulators and inhibitors. A number of endogenous angiogenesis inhibitors have been found in the body. The origin of these inhibitors is mostly extrinsic to the vasculature. Recently, however, vascular endothelial cells themselves have been found to produce angiogenesis inhibitors including vasohibin-1. These intrinsic inhibitors are thought to regulate angiogenesis by an auto-regulatory or negative-feedback mechanism. This review will focus on vasohibin-1 produced by vascular endothelial cells and on its homologue, vasohibin-2.
Keywords: endothelial cell; negative feedback; mononuclear cell; bone marrow