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The Chick Embryo Chorioallantoic Membrane as an In Vivo Assay to Study Antiangiogenesis
Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11, Policlinico 70124, Bari, Italy
Received: 12 January 2010; in revised form: 29 January 2010 / Accepted: 2 March 2010 / Published: 8 March 2010
Abstract: Antiangiogenesis, e.g., inhibition of blood vessel growth, is being investigated as a way to prevent the growth of tumors and other angiogenesis-dependent diseases. Pharmacological inhibition interferes with the angiogenic cascade or the immature neovasculature with synthetic or semi-synthetic substances, endogenous inhibitors or biological antagonists.The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane, which serves as a gas exchange surface and its function is supported by a dense capillary network. Because its extensive vascularization and easy accessibility, CAM has been used to study morphofunctional aspects of the angiogenesis process in vivo and to study the efficacy and mechanism of action of pro- and anti-angiogenic molecules. The fields of application of CAM in the study of antiangiogenesis, including our personal experience, are illustrated in this review article.
Keywords: antiangiogenesis; chorioallantoic membrane; tumor progression
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Ribatti, D. The Chick Embryo Chorioallantoic Membrane as an In Vivo Assay to Study Antiangiogenesis. Pharmaceuticals 2010, 3, 482-513.
Ribatti D. The Chick Embryo Chorioallantoic Membrane as an In Vivo Assay to Study Antiangiogenesis. Pharmaceuticals. 2010; 3(3):482-513.
Ribatti, Domenico. 2010. "The Chick Embryo Chorioallantoic Membrane as an In Vivo Assay to Study Antiangiogenesis." Pharmaceuticals 3, no. 3: 482-513.