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Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies
Departments of Neurology and Molecular and Integrative Physiology, University of Kansas School of Medicine, Kansas City, MO, Kansas 66160, USA
Received: 19 November 2009; in revised form: 27 November 2009 / Accepted: 2 December 2009 / Published: 3 December 2009
Abstract: Neurodegenerative diseases are a common late-life scourge for which diseasemodifying treatments are sorely needed. Mitochondrial perturbation is commonly observed in these diseases, so pursuing treatment development strategies that target mitochondria or processes affected by mitochondria seems reasonable. This review discusses the rationale underlying past and current efforts to treat neurodegenerative diseases using mitochondrial medicine, and tries to predict how future efforts might proceed.
Keywords: mitochondria; mitochondrial biogenesis; mitochondriopathies; neurodegenerative diseases; oxidative stress
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Swerdlow, R.H. Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies. Pharmaceuticals 2009, 2, 150-167.
Swerdlow RH. Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies. Pharmaceuticals. 2009; 2(3):150-167.
Swerdlow, Russell H. 2009. "Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies." Pharmaceuticals 2, no. 3: 150-167.