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Pharmaceuticals 2009, 2(3), 150-167; doi:10.3390/ph2030150

Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies

Departments of Neurology and Molecular and Integrative Physiology, University of Kansas School of Medicine, Kansas City, MO, Kansas 66160, USA
Received: 19 November 2009 / Revised: 27 November 2009 / Accepted: 2 December 2009 / Published: 3 December 2009
(This article belongs to the Special Issue Mitochondrial Drugs for Neurodegenerative Diseases)
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Neurodegenerative diseases are a common late-life scourge for which diseasemodifying treatments are sorely needed. Mitochondrial perturbation is commonly observed in these diseases, so pursuing treatment development strategies that target mitochondria or processes affected by mitochondria seems reasonable. This review discusses the rationale underlying past and current efforts to treat neurodegenerative diseases using mitochondrial medicine, and tries to predict how future efforts might proceed.
Keywords: mitochondria; mitochondrial biogenesis; mitochondriopathies; neurodegenerative diseases; oxidative stress mitochondria; mitochondrial biogenesis; mitochondriopathies; neurodegenerative diseases; oxidative stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Swerdlow, R.H. Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies. Pharmaceuticals 2009, 2, 150-167.

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