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Pharmaceuticals 2018, 11(2), 39; https://doi.org/10.3390/ph11020039

Iron Release from Soybean Seed Ferritin Induced by Cinnamic Acid Derivatives

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, Beijing Key Laboratory of Functional Food from Plant Resources, China Agricultural University, Beijing 100083, China
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Received: 4 March 2018 / Revised: 15 April 2018 / Accepted: 2 May 2018 / Published: 4 May 2018
(This article belongs to the Special Issue Iron as Therapeutic Targets in Human Diseases)
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Abstract

Plant ferritin represents a novel class of iron supplement, which widely co-exists with phenolic acids in a plant diet. However, there are few reports on the effect of these phenolic acids on function of ferritin. In this study, we demonstrated that cinnamic acid derivatives, as widely occurring phenolic acids, can induce iron release from holo soybean seed ferritin (SSF) in a structure-dependent manner. The ability of the iron release from SSF by five cinnamic acids follows the sequence of Cinnamic acid > Chlorogenic acid > Ferulic acid > p-Coumaric acid > Trans-Cinnamic acid. Fluorescence titration in conjunction with dialysis results showed that all of these five compounds have a similar, weak ability to bind with protein, suggesting that their protein-binding ability is not related to their iron release activity. In contrast, both Fe2+-chelating activity and reducibility of these cinnamic acid derivatives are in good agreement with their ability to induce iron release from ferritin. These studies indicate that cinnamic acid and its derivatives could have a negative effect on iron stability of holo soybean seed ferritin in diet, and the Fe2+-chelating activity and reducibility of cinnamic acid and its derivatives have strong relations to the iron release of soybean seed ferritin. View Full-Text
Keywords: cinnamic acid derivatives; soybean seed ferritin; iron release; binding ability; Fe2+-chelating activity; reducibility cinnamic acid derivatives; soybean seed ferritin; iron release; binding ability; Fe2+-chelating activity; reducibility
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Sha, X.; Chen, H.; Zhang, J.; Zhao, G. Iron Release from Soybean Seed Ferritin Induced by Cinnamic Acid Derivatives. Pharmaceuticals 2018, 11, 39.

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