Next Article in Journal
Pharmaceuticals: Impact Factor or CiteScore™
Next Article in Special Issue
Systemic Interleukin-4 Administration after Spinal Cord Injury Modulates Inflammation and Promotes Neuroprotection
Previous Article in Journal
Synthesis and Antiproliferative Activity of Novel Heterocyclic Indole-Trimethoxyphenyl Conjugates
Previous Article in Special Issue
Exploring Wound-Healing Genomic Machinery with a Network-Based Approach
Article Menu
Issue 3 (September) cover image

Export Article

Open AccessReview
Pharmaceuticals 2017, 10(3), 63; doi:10.3390/ph10030063

Nanofiber Scaffolds as Drug Delivery Systems to Bridge Spinal Cord Injury

Department of Drug Sciences, University of Pavia, Viale Taramelli, 12, 27100 Pavia, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 10 May 2017 / Revised: 13 June 2017 / Accepted: 1 July 2017 / Published: 5 July 2017
(This article belongs to the Special Issue Tissue-Protective Agents: New Drugs and Technologies)
View Full-Text   |   Download PDF [1347 KB, uploaded 11 July 2017]   |  

Abstract

The complex pathophysiology of spinal cord injury (SCI) may explain the current lack of an effective therapeutic approach for the regeneration of damaged neuronal cells and the recovery of motor functions. A primary mechanical injury in the spinal cord triggers a cascade of secondary events, which are involved in SCI instauration and progression. The aim of the present review is to provide an overview of the therapeutic neuro-protective and neuro-regenerative approaches, which involve the use of nanofibers as local drug delivery systems. Drugs released by nanofibers aim at preventing the cascade of secondary damage (neuro-protection), whereas nanofibrous structures are intended to re-establish neuronal connectivity through axonal sprouting (neuro-regeneration) promotion, in order to achieve a rapid functional recovery of spinal cord. View Full-Text
Keywords: spinal cord injury; nanofibers; electrospinning; neuroprotection; neuroregeneration spinal cord injury; nanofibers; electrospinning; neuroprotection; neuroregeneration
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Faccendini, A.; Vigani, B.; Rossi, S.; Sandri, G.; Bonferoni, M.C.; Caramella, C.M.; Ferrari, F. Nanofiber Scaffolds as Drug Delivery Systems to Bridge Spinal Cord Injury. Pharmaceuticals 2017, 10, 63.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top