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Pharmaceuticals 2017, 10(1), 28; doi:10.3390/ph10010028

Targeted Drugs as Maintenance Therapy after Autologous Stem Cell Transplantation in Patients with Mantle Cell Lymphoma

1
Department of Medicine, University of Washington, Seattle, WA 98195, USA
2
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
3
Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Luciano J. Costa
Received: 27 January 2017 / Revised: 6 March 2017 / Accepted: 8 March 2017 / Published: 10 March 2017
(This article belongs to the Special Issue New Drugs in Hematology)
View Full-Text   |   Download PDF [233 KB, uploaded 13 March 2017]

Abstract

The treatment landscape for mantle cell lymphoma (MCL) is rapidly evolving toward the incorporation of novel and biologically targeted pharmaceuticals with improved disease activity and gentler toxicity profiles compared with conventional chemotherapeutics. Upfront intensive treatment of MCL includes autologous stem cell transplantation (SCT) consolidation aimed at deepening and lengthening disease remission, but subsequent relapse occurs. Maintenance therapy after autologous SCT in patients with MCL in remission features lower-intensity treatments given over extended periods to improve disease outcomes. Targeted drugs are a natural fit for this space, and are the focus of considerable clinical investigation. This review summarizes recent advances in the field and their potential impact on treatment practices for MCL. View Full-Text
Keywords: stem cell transplantation; mantle cell lymphoma; maintenance therapy stem cell transplantation; mantle cell lymphoma; maintenance therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yan, F.; Gopal, A.K.; Graf, S.A. Targeted Drugs as Maintenance Therapy after Autologous Stem Cell Transplantation in Patients with Mantle Cell Lymphoma. Pharmaceuticals 2017, 10, 28.

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