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Sensors 2009, 9(8), 6298-6311; doi:10.3390/s90806298

Bacteriophage T4 Nanoparticles as Materials in Sensor Applications: Variables That Influence Their Organization and Assembly on Surfaces

U.S. Naval Research Laboratory/4555 Overlook Ave., SW, Center for Biomolecular Science and Engineering, Washington, D.C. 20375, USA
Author to whom correspondence should be addressed.
Received: 1 July 2009 / Revised: 21 July 2009 / Accepted: 10 August 2009 / Published: 12 August 2009
(This article belongs to the Section Biosensors)
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Bacteriophage T4 nanoparticles possess characteristics that make them ideal candidates as materials for sensors, particularly as sensor probes. Their surface can be modified, either through genetic engineering or direct chemical conjugation to display functional moieties such as antibodies or other proteins to recognize a specific target. However, in order for T4 nanoparticles to be utilized as a sensor probe, it is necessary to understand and control the variables that determine their assembly and organization on a surface. The aim of this work is to discuss some of variables that we have identified as influencing the behavior of T4 nanoparticles on surfaces. The effect of pH, ionic strength, substrate characteristics, nanoparticle concentration and charge was addressed qualitatively using atomic force microscopy (AFM). View Full-Text
Keywords: bacteriophage T4; sensors; atomic force microscopy bacteriophage T4; sensors; atomic force microscopy

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Archer, M.J.; Liu, J.L. Bacteriophage T4 Nanoparticles as Materials in Sensor Applications: Variables That Influence Their Organization and Assembly on Surfaces. Sensors 2009, 9, 6298-6311.

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