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Sensors 2009, 9(8), 6298-6311; doi:10.3390/s90806298
Article

Bacteriophage T4 Nanoparticles as Materials in Sensor Applications: Variables That Influence Their Organization and Assembly on Surfaces

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Received: 1 July 2009; in revised form: 21 July 2009 / Accepted: 10 August 2009 / Published: 12 August 2009
(This article belongs to the Section Biosensors)
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Abstract: Bacteriophage T4 nanoparticles possess characteristics that make them ideal candidates as materials for sensors, particularly as sensor probes. Their surface can be modified, either through genetic engineering or direct chemical conjugation to display functional moieties such as antibodies or other proteins to recognize a specific target. However, in order for T4 nanoparticles to be utilized as a sensor probe, it is necessary to understand and control the variables that determine their assembly and organization on a surface. The aim of this work is to discuss some of variables that we have identified as influencing the behavior of T4 nanoparticles on surfaces. The effect of pH, ionic strength, substrate characteristics, nanoparticle concentration and charge was addressed qualitatively using atomic force microscopy (AFM).
Keywords: bacteriophage T4; sensors; atomic force microscopy bacteriophage T4; sensors; atomic force microscopy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Archer, M.J.; Liu, J.L. Bacteriophage T4 Nanoparticles as Materials in Sensor Applications: Variables That Influence Their Organization and Assembly on Surfaces. Sensors 2009, 9, 6298-6311.

AMA Style

Archer MJ, Liu JL. Bacteriophage T4 Nanoparticles as Materials in Sensor Applications: Variables That Influence Their Organization and Assembly on Surfaces. Sensors. 2009; 9(8):6298-6311.

Chicago/Turabian Style

Archer, Marie J.; Liu, Jinny L. 2009. "Bacteriophage T4 Nanoparticles as Materials in Sensor Applications: Variables That Influence Their Organization and Assembly on Surfaces." Sensors 9, no. 8: 6298-6311.


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