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Fabrication of Pillar Shaped Electrode Arrays for Artificial Retinal Implants
School of Electrical Engineering and Computer Science
Department of Ophthalmology, College of Medicine and Seoul Artificial Eye Center, Nano Bioelectronics & System Research Center (NBS-ERC), Seoul National University, Seoul, Korea
* Author to whom correspondence should be addressed.
Received: 21 August 2008; in revised form: 22 September 2008 / Accepted: 23 September 2008 / Published: 24 September 2008
Abstract: Polyimide has been widely applied to neural prosthetic devices, such as the retinal implants, due to its well-known biocompatibility and ability to be micropatterned. However, planar films of polyimide that are typically employed show a limited ability in reducing the distance between electrodes and targeting cell layers, which limits site resolution for effective multi-channel stimulation. In this paper, we report a newly designed device with a pillar structure that more effectively interfaces with the target. Electrode arrays were successfully fabricated and safely implanted inside the rabbit eye in suprachoroidal space. Optical Coherence Tomography (OCT) showed well-preserved pillar structures of the electrode without damage. Bipolar stimulation was applied through paired sites (6:1) and the neural responses were successfully recorded from several regions in the visual cortex. Electrically evoked cortical potential by the pillar electrode array stimulation were compared to visual evoked potential under full-field light stimulation.
Keywords: Polyimide; retinal implant; pillar; optical coherence tomography; electrically evoked cortical potential
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MDPI and ACS Style
Kim, E.T.; Seo, J.-M.; Woo, S.J.; Zhou, J.A.; Chung, H.; Kim, S.J. Fabrication of Pillar Shaped Electrode Arrays for Artificial Retinal Implants. Sensors 2008, 8, 5845-5856.
Kim ET, Seo J-M, Woo SJ, Zhou JA, Chung H, Kim SJ. Fabrication of Pillar Shaped Electrode Arrays for Artificial Retinal Implants. Sensors. 2008; 8(9):5845-5856.
Kim, Eui T.; Seo, Jong-Mo; Woo, Se J.; Zhou, Jing A.; Chung, Hum; Kim, Sung J. 2008. "Fabrication of Pillar Shaped Electrode Arrays for Artificial Retinal Implants." Sensors 8, no. 9: 5845-5856.