Next Article in Journal
Determination of the Content of Heavy Metals in Pyrite Contaminated Soil and Plants
Previous Article in Journal
A Voltammetric Biosensor Based on Glassy Carbon Electrodes Modified with Single-Walled Carbon Nanotubes/Hemoglobin for Detection of Acrylamide in Water Extracts from Potato Crisps
Sensors 2008, 8(9), 5845-5856; doi:10.3390/s8095845
Article

Fabrication of Pillar Shaped Electrode Arrays for Artificial Retinal Implants

1
, 1
, 2
, 1
, 2
 and 1,*
Received: 21 August 2008; in revised form: 22 September 2008 / Accepted: 23 September 2008 / Published: 24 September 2008
View Full-Text   |   Download PDF [1553 KB, uploaded 21 June 2014]   |   Browse Figures
Abstract: Polyimide has been widely applied to neural prosthetic devices, such as the retinal implants, due to its well-known biocompatibility and ability to be micropatterned. However, planar films of polyimide that are typically employed show a limited ability in reducing the distance between electrodes and targeting cell layers, which limits site resolution for effective multi-channel stimulation. In this paper, we report a newly designed device with a pillar structure that more effectively interfaces with the target. Electrode arrays were successfully fabricated and safely implanted inside the rabbit eye in suprachoroidal space. Optical Coherence Tomography (OCT) showed well-preserved pillar structures of the electrode without damage. Bipolar stimulation was applied through paired sites (6:1) and the neural responses were successfully recorded from several regions in the visual cortex. Electrically evoked cortical potential by the pillar electrode array stimulation were compared to visual evoked potential under full-field light stimulation.
Keywords: Polyimide; retinal implant; pillar; optical coherence tomography; electrically evoked cortical potential Polyimide; retinal implant; pillar; optical coherence tomography; electrically evoked cortical potential
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Kim, E.T.; Seo, J.-M.; Woo, S.J.; Zhou, J.A.; Chung, H.; Kim, S.J. Fabrication of Pillar Shaped Electrode Arrays for Artificial Retinal Implants. Sensors 2008, 8, 5845-5856.

AMA Style

Kim ET, Seo J-M, Woo SJ, Zhou JA, Chung H, Kim SJ. Fabrication of Pillar Shaped Electrode Arrays for Artificial Retinal Implants. Sensors. 2008; 8(9):5845-5856.

Chicago/Turabian Style

Kim, Eui T.; Seo, Jong-Mo; Woo, Se J.; Zhou, Jing A.; Chung, Hum; Kim, Sung J. 2008. "Fabrication of Pillar Shaped Electrode Arrays for Artificial Retinal Implants." Sensors 8, no. 9: 5845-5856.


Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert