Sensors 2008, 8(6), 3952-3969; doi:10.3390/s8063952
Article

Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode

1 University of Medicine and Pharmacy “Victor Babes” Timisoara, PiaŃa E. Murgu, Nr. 2, 300041 Timisoara, Romania 2 West University of Timisoara, Laboratory of Electrochemistry, Str. Pestalozzi Nr.16, 300115 Timisoara, Romania
* Author to whom correspondence should be addressed.
Received: 21 May 2008; in revised form: 9 June 2008 / Accepted: 9 June 2008 / Published: 12 June 2008
PDF Full-text Download PDF Full-Text [512 KB, uploaded 16 September 2008 11:02 CEST]
Abstract: Cyclic voltammetry (CV) and chronoamperometry (CA) have been used to sense and determine simultaneously L-ascorbic acid (AA) and acetaminophen (AC) at a boron-doped diamond electrode (BDDE) in a Britton-Robinson buffer solution. The calibration plots of anodic current peak versus concentration obtained from CV and CA data for both investigated compounds in single and di-component solutions over the concentration range 0.01 mM – 0.1 mM proved to be linear, with very good correlation parameters. Sensitivity values and RSD of 2-3% were obtained for various situations, involving both individual and simultaneous presence of AA and AC. The chronoamperometric technique associated with standard addition in sequential one step and/or two successive and continuous chronoamperograms at two characteristic potential levels represented a feasible option for the simultaneous determination of AA and AC in real sample systems such as pharmaceutical formulations. The average values indicated by the supplier were confirmed to a very close approximation from chronoamperomgrams by using several additions with the application of suitable current correction factors.
Keywords: acetaminophen; ascorbic acid; chronoamperometry; boron-doped diamond electrode; buffered media.

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Cofan, C.; Radovan, C. Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode. Sensors 2008, 8, 3952-3969.

AMA Style

Cofan C, Radovan C. Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode. Sensors. 2008; 8(6):3952-3969.

Chicago/Turabian Style

Cofan, Codruţa; Radovan, Ciprian. 2008. "Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode." Sensors 8, no. 6: 3952-3969.

Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert