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Sensors 2008, 8(6), 3952-3969; doi:10.3390/s8063952

Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode

1
University of Medicine and Pharmacy “Victor Babes” Timisoara, PiaŃa E. Murgu, Nr. 2, 300041 Timisoara, Romania
2
West University of Timisoara, Laboratory of Electrochemistry, Str. Pestalozzi Nr.16, 300115 Timisoara, Romania
*
Author to whom correspondence should be addressed.
Received: 21 May 2008 / Revised: 9 June 2008 / Accepted: 9 June 2008 / Published: 12 June 2008
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Abstract

Cyclic voltammetry (CV) and chronoamperometry (CA) have been used to sense and determine simultaneously L-ascorbic acid (AA) and acetaminophen (AC) at a boron-doped diamond electrode (BDDE) in a Britton-Robinson buffer solution. The calibration plots of anodic current peak versus concentration obtained from CV and CA data for both investigated compounds in single and di-component solutions over the concentration range 0.01 mM – 0.1 mM proved to be linear, with very good correlation parameters. Sensitivity values and RSD of 2-3% were obtained for various situations, involving both individual and simultaneous presence of AA and AC. The chronoamperometric technique associated with standard addition in sequential one step and/or two successive and continuous chronoamperograms at two characteristic potential levels represented a feasible option for the simultaneous determination of AA and AC in real sample systems such as pharmaceutical formulations. The average values indicated by the supplier were confirmed to a very close approximation from chronoamperomgrams by using several additions with the application of suitable current correction factors. View Full-Text
Keywords: acetaminophen; ascorbic acid; chronoamperometry; boron-doped diamond electrode; buffered media. acetaminophen; ascorbic acid; chronoamperometry; boron-doped diamond electrode; buffered media.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Cofan, C.; Radovan, C. Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode. Sensors 2008, 8, 3952-3969.

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