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Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode
University of Medicine and Pharmacy “Victor Babes” Timisoara, PiaŃa E. Murgu, Nr. 2, 300041 Timisoara, Romania
West University of Timisoara, Laboratory of Electrochemistry, Str. Pestalozzi Nr.16, 300115 Timisoara, Romania
* Author to whom correspondence should be addressed.
Received: 21 May 2008; in revised form: 9 June 2008 / Accepted: 9 June 2008 / Published: 12 June 2008
Abstract: Cyclic voltammetry (CV) and chronoamperometry (CA) have been used to sense and determine simultaneously L-ascorbic acid (AA) and acetaminophen (AC) at a boron-doped diamond electrode (BDDE) in a Britton-Robinson buffer solution. The calibration plots of anodic current peak versus concentration obtained from CV and CA data for both investigated compounds in single and di-component solutions over the concentration range 0.01 mM – 0.1 mM proved to be linear, with very good correlation parameters. Sensitivity values and RSD of 2-3% were obtained for various situations, involving both individual and simultaneous presence of AA and AC. The chronoamperometric technique associated with standard addition in sequential one step and/or two successive and continuous chronoamperograms at two characteristic potential levels represented a feasible option for the simultaneous determination of AA and AC in real sample systems such as pharmaceutical formulations. The average values indicated by the supplier were confirmed to a very close approximation from chronoamperomgrams by using several additions with the application of suitable current correction factors.
Keywords: acetaminophen; ascorbic acid; chronoamperometry; boron-doped diamond electrode; buffered media.
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Cite This Article
MDPI and ACS Style
Cofan, C.; Radovan, C. Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode. Sensors 2008, 8, 3952-3969.
Cofan C, Radovan C. Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode. Sensors. 2008; 8(6):3952-3969.
Cofan, Codruţa; Radovan, Ciprian. 2008. "Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode." Sensors 8, no. 6: 3952-3969.