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Sensors 2008, 8(6), 3952-3969; doi:10.3390/s8063952
Article

Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode

1,*  and 2
Received: 21 May 2008; in revised form: 9 June 2008 / Accepted: 9 June 2008 / Published: 12 June 2008
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Abstract: Cyclic voltammetry (CV) and chronoamperometry (CA) have been used to sense and determine simultaneously L-ascorbic acid (AA) and acetaminophen (AC) at a boron-doped diamond electrode (BDDE) in a Britton-Robinson buffer solution. The calibration plots of anodic current peak versus concentration obtained from CV and CA data for both investigated compounds in single and di-component solutions over the concentration range 0.01 mM – 0.1 mM proved to be linear, with very good correlation parameters. Sensitivity values and RSD of 2-3% were obtained for various situations, involving both individual and simultaneous presence of AA and AC. The chronoamperometric technique associated with standard addition in sequential one step and/or two successive and continuous chronoamperograms at two characteristic potential levels represented a feasible option for the simultaneous determination of AA and AC in real sample systems such as pharmaceutical formulations. The average values indicated by the supplier were confirmed to a very close approximation from chronoamperomgrams by using several additions with the application of suitable current correction factors.
Keywords: acetaminophen; ascorbic acid; chronoamperometry; boron-doped diamond electrode; buffered media. acetaminophen; ascorbic acid; chronoamperometry; boron-doped diamond electrode; buffered media.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Cofan, C.; Radovan, C. Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode. Sensors 2008, 8, 3952-3969.

AMA Style

Cofan C, Radovan C. Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode. Sensors. 2008; 8(6):3952-3969.

Chicago/Turabian Style

Cofan, Codruţa; Radovan, Ciprian. 2008. "Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode." Sensors 8, no. 6: 3952-3969.


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