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Sensors 2008, 8(6), 3903-3931; doi:10.3390/s8063903

Interferometric Synthetic Aperture Microscopy: Computed Imaging for Scanned Coherent Microscopy

The Beckman Institute for Advanced Science and Technology, and The Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, IL 61801, USA
* Author to whom correspondence should be addressed.
Received: 5 June 2008 / Revised: 9 June 2008 / Accepted: 9 June 2008 / Published: 11 June 2008
(This article belongs to the Special Issue Synthetic Aperture Radar (SAR))
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Three-dimensional image formation in microscopy is greatly enhanced by the use of computed imaging techniques. In particular, Interferometric Synthetic Aperture Microscopy (ISAM) allows the removal of out-of-focus blur in broadband, coherent microscopy. Earlier methods, such as optical coherence tomography (OCT), utilize interferometric ranging, but do not apply computed imaging methods and therefore must scan the focal depth to acquire extended volumetric images. ISAM removes the need to scan the focus by allowing volumetric image reconstruction from data collected at a single focal depth. ISAM signal processing techniques are similar to the Fourier migration methods of seismology and the Fourier reconstruction methods of Synthetic Aperture Radar (SAR). In this article ISAM is described and the close ties between ISAM and SAR are explored. ISAM and a simple strip-map SAR system are placed in a common mathematical framework and compared to OCT and radar respectively. This article is intended to serve as a review of ISAM, and will be especially useful to readers with a background in SAR.
Keywords: Microscopy; Interferometric; Synthetic Aperture; Radar; Optical Coherence Tomography. Microscopy; Interferometric; Synthetic Aperture; Radar; Optical Coherence Tomography.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Davis, B.J.; Marks, D.L.; Ralston, T.S.; Carney, P.S.; Boppart, S.A. Interferometric Synthetic Aperture Microscopy: Computed Imaging for Scanned Coherent Microscopy. Sensors 2008, 8, 3903-3931.

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