Sensors 2008, 8(6), 3689-3705; doi:10.3390/s8063689
Article

Fluorescent Indolizine-b-Cyclodextrin Derivatives for the Detection of Volatile Organic Compounds

, , ,  and * email
Received: 23 April 2008; in revised form: 25 May 2008 / Accepted: 29 May 2008 / Published: 2 June 2008
(This article belongs to the Special Issue Supramolecular Sensors)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: This paper presents the synthesis, the structural determination and the sensing capabilities toward Volatile Organic Compounds (VOCs) of a new class of fluorescent indolizine-cyclodextrin sensors. Two different pathways, both involving bipyridinium ylides and 6-amino-b-cyclodextrin, have been used to carry out the synthesis of these sensors. The macrocycle structures were dominantly established by 1H-NMR spectra and systematically studied by molecular modelling (MM3, AM1, AM1-COSMO methods). The sensing capabilities of the sensors were evaluated by emission of fluorescence, during the inclusion of the guest (adamantanol or aromatic derivatives) into the cyclodextrin (CD) host cavity. The host/guest complex formation was investigated by formation constant determinations, using experimental methods, coupled with theoretical calculations of formation energies using a specific docking procedure. Both experimental and theoretical results suggest that some compounds would make very attractive sensors for VOC detection. Some compounds could also be taken into consideration as biological markers.
Keywords: Indolizine-b-cyclodextrin; sensor; formation constants; docking; sensing capabilities; detection; Volatile Organic Compounds
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MDPI and ACS Style

Becuwe, M.; Landy, D.; Delattre, F.; Cazier, F.; Fourmentin, S. Fluorescent Indolizine-b-Cyclodextrin Derivatives for the Detection of Volatile Organic Compounds. Sensors 2008, 8, 3689-3705.

AMA Style

Becuwe M, Landy D, Delattre F, Cazier F, Fourmentin S. Fluorescent Indolizine-b-Cyclodextrin Derivatives for the Detection of Volatile Organic Compounds. Sensors. 2008; 8(6):3689-3705.

Chicago/Turabian Style

Becuwe, Matthieu; Landy, David; Delattre, François; Cazier, Francine; Fourmentin, Sophie. 2008. "Fluorescent Indolizine-b-Cyclodextrin Derivatives for the Detection of Volatile Organic Compounds." Sensors 8, no. 6: 3689-3705.

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