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Flow-Injection Coulometric Detection Based on Ion Transfer and Its Application to the Determination of Chlorpromazine
Department of Analytical Chemistry, Faculty of Chemistry, Campus de Espinardo, University of Murcia, 30071-Murcia, Spain
* Author to whom correspondence should be addressed.
Received: 2 April 2008; in revised form: 29 May 2008 / Accepted: 29 May 2008 / Published: 1 June 2008
Abstract: A flow-injection coulometric method for the determination of chlorpromazine based on ion transfer into a plasticized poly(vinyl chloride) (PVC) membrane, was developed. The detector used consists of a flow-through cell that incorporates a plasticized poly(vinyl chloride) (PVC) membrane which contains tetrabutylammonium tetraphenylborate as electrolyte. The membrane is located between the flowing solution and an inner aqueous electrolyte solution. Two pairs of electrodes, each pair formed by a reference electrode and a working electrode, are used, one pair in each solution. The potential between the reference electrodes was controlled by a four-electrode potentiostat with ohmic drop compensation. A potential step capable of producing the transfer of the chlorpromazine ion into the membrane was applied during the passage of a wide portion of sample plug through the cell and the corresponding quantity of the electricity was measured. In the selected conditions, a linear relationship was observed between the quantity of electricity and chlorpromazine concentrations over a range of 1x10-6 -1x10-4 M. The detection limit was 2 x 10-7 M. Good repeatability and between-day reproducibility was obtained. No interference was observed on the part of some common ions and pharmaceutical excipients. The method proposed was applied satisfactorily to the determination of chlorpromazine in pharmaceuticals and human urine.
Keywords: Interface between Two Immiscible Electrolyte Solutions; ion transfer; coulometry; chlorpromazine determination; flow-injection analysis
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Cite This Article
MDPI and ACS Style
Ortuño, J.A.; Gil, A.; Sánchez-Pedreño, C. Flow-Injection Coulometric Detection Based on Ion Transfer and Its Application to the Determination of Chlorpromazine. Sensors 2008, 8, 3678-3688.
Ortuño JA, Gil A, Sánchez-Pedreño C. Flow-Injection Coulometric Detection Based on Ion Transfer and Its Application to the Determination of Chlorpromazine. Sensors. 2008; 8(6):3678-3688.
Ortuño, Joaquín A.; Gil, Antonio; Sánchez-Pedreño, Concepción. 2008. "Flow-Injection Coulometric Detection Based on Ion Transfer and Its Application to the Determination of Chlorpromazine." Sensors 8, no. 6: 3678-3688.