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Sensors 2008, 8(10), 6605-6641; doi:10.3390/s8106605
Review

Molecular Recognition and Specific Interactions for Biosensing Applications

 and *
Received: 25 September 2008; in revised form: 16 October 2008 / Accepted: 20 October 2008 / Published: 23 October 2008
(This article belongs to the Special Issue Molecular Recognition and Sensors, Including Molecular Imprinting)
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Abstract: Molecular recognition and specific interactions are reliable and versatile routes for site-specific and well-oriented immobilization of functional biomolecules on surfaces. The control of surface properties via the molecular recognition and specific interactions at the nanoscale is a key element for the nanofabrication of biosensors with high sensitivity and specificity. This review intends to provide a comprehensive understanding of the molecular recognition- and specific interaction-mediated biosensor fabrication routes that leads to biosensors with well-ordered and controlled structures on both nanopatterned surfaces and nanomaterials. Herein self-assembly of the biomolecules via the molecular recognition and specific interactions on nanoscaled surfaces as well as nanofabrication techniques of the biomolecules for biosensor architecture are discussed. We also describe the detection of molecular recognition- and specific interaction-mediated molecular binding as well as advantages of nanoscale detection.
Keywords: Molecular recognition; specific interaction; biosensor; nanopatterning; nanomaterial Molecular recognition; specific interaction; biosensor; nanopatterning; nanomaterial
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kim, D.C.; Kang, D.J. Molecular Recognition and Specific Interactions for Biosensing Applications. Sensors 2008, 8, 6605-6641.

AMA Style

Kim DC, Kang DJ. Molecular Recognition and Specific Interactions for Biosensing Applications. Sensors. 2008; 8(10):6605-6641.

Chicago/Turabian Style

Kim, Dong C.; Kang, Dae J. 2008. "Molecular Recognition and Specific Interactions for Biosensing Applications." Sensors 8, no. 10: 6605-6641.


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