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Sensors 2007, 7(8), 1480-1495; doi:10.3390/s7081480
Article

Formation and Characterization of Self-Assembled Phenylboronic Acid Derivative Monolayers toward Developing Monosaccaride Sensing-Interface

1, 2, 3, 4, 5, 3, 3 and 3,*
Received: 1 July 2007; Accepted: 1 August 2007 / Published: 1 August 2007
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Abstract: We designed and synthesized phenylboronic acid as a molecular recognitionmodel system for saccharide detection. The phenylboronic acid derivatives that haveboronic acid moiety are well known to interact with saccharides in aqueous solution; thus,they can be applied to a functional interface of saccharide sensing through the formation ofself-assembled monolayer (SAM). In this study, self-assembled phenylboronic acidderivative monolayers were formed on Au surface and carefully characterized by atomicforce microscopy (AFM), Fourier transform infrared reflection absorption spectroscopy(FTIR-RAS), surface enhanced Raman spectroscopy (SERS), and surface electrochemicalmeasurements. The saccharide sensing application was investigated using surface plasmonresonance (SPR) spectroscopy. The phenylboronic acid monolayers showed goodsensitivity of monosaccharide sensing even at the low concentration range (1.0 × 10-12 M).The SPR angle shift derived from interaction between phenylboronic acid andmonosaccharide was increased with increasing the alkyl spacer length of synthesizedphenylboronic acid derivatives.
Keywords: phenylboronic acid; self-assembled monolayer; saccharide detection; surface plasmon resonance. phenylboronic acid; self-assembled monolayer; saccharide detection; surface plasmon resonance.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, H.; Lee, M.; Lee, J.; Kim, J.-H.; Gal, Y.-S.; Hwang, Y.-H.; An, W.G.; Koh, K. Formation and Characterization of Self-Assembled Phenylboronic Acid Derivative Monolayers toward Developing Monosaccaride Sensing-Interface. Sensors 2007, 7, 1480-1495.

AMA Style

Chen H, Lee M, Lee J, Kim J-H, Gal Y-S, Hwang Y-H, An WG, Koh K. Formation and Characterization of Self-Assembled Phenylboronic Acid Derivative Monolayers toward Developing Monosaccaride Sensing-Interface. Sensors. 2007; 7(8):1480-1495.

Chicago/Turabian Style

Chen, Hongxia; Lee, Minsu; Lee, Jaebeom; Kim, Jae-Ho; Gal, Yeong-Soon; Hwang, Yoon-Hwae; An, Won G.; Koh, Kwangnak. 2007. "Formation and Characterization of Self-Assembled Phenylboronic Acid Derivative Monolayers toward Developing Monosaccaride Sensing-Interface." Sensors 7, no. 8: 1480-1495.


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