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Formation and Characterization of Self-Assembled Phenylboronic Acid Derivative Monolayers toward Developing Monosaccaride Sensing-Interface
College of Pharmacy, Pusan National University, Pusan 609-735, Korea
SEED BioChips Inc., Chung-Buk Technopark, Oh-Chang, Chung-Buk 363-883, Korea
College of Nanoscience and Nanotechnology, Pusan National University, Pusan 609-735, Korea
Department of Molecular Science and Technology, Ajou University, Suwon, Korea
Chemistry Division, Kyungil University, Kyungsanbuk-do 712-701, Korea
* Author to whom correspondence should be addressed.
Received: 1 July 2007 / Accepted: 1 August 2007 / Published: 1 August 2007
Abstract: We designed and synthesized phenylboronic acid as a molecular recognitionmodel system for saccharide detection. The phenylboronic acid derivatives that haveboronic acid moiety are well known to interact with saccharides in aqueous solution; thus,they can be applied to a functional interface of saccharide sensing through the formation ofself-assembled monolayer (SAM). In this study, self-assembled phenylboronic acidderivative monolayers were formed on Au surface and carefully characterized by atomicforce microscopy (AFM), Fourier transform infrared reflection absorption spectroscopy(FTIR-RAS), surface enhanced Raman spectroscopy (SERS), and surface electrochemicalmeasurements. The saccharide sensing application was investigated using surface plasmonresonance (SPR) spectroscopy. The phenylboronic acid monolayers showed goodsensitivity of monosaccharide sensing even at the low concentration range (1.0 × 10-12 M).The SPR angle shift derived from interaction between phenylboronic acid andmonosaccharide was increased with increasing the alkyl spacer length of synthesizedphenylboronic acid derivatives.
Keywords: phenylboronic acid; self-assembled monolayer; saccharide detection; surface plasmon resonance.
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MDPI and ACS Style
Chen, H.; Lee, M.; Lee, J.; Kim, J.-H.; Gal, Y.-S.; Hwang, Y.-H.; An, W.G.; Koh, K. Formation and Characterization of Self-Assembled Phenylboronic Acid Derivative Monolayers toward Developing Monosaccaride Sensing-Interface. Sensors 2007, 7, 1480-1495.
Chen H, Lee M, Lee J, Kim J-H, Gal Y-S, Hwang Y-H, An WG, Koh K. Formation and Characterization of Self-Assembled Phenylboronic Acid Derivative Monolayers toward Developing Monosaccaride Sensing-Interface. Sensors. 2007; 7(8):1480-1495.
Chen, Hongxia; Lee, Minsu; Lee, Jaebeom; Kim, Jae-Ho; Gal, Yeong-Soon; Hwang, Yoon-Hwae; An, Won G.; Koh, Kwangnak. 2007. "Formation and Characterization of Self-Assembled Phenylboronic Acid Derivative Monolayers toward Developing Monosaccaride Sensing-Interface." Sensors 7, no. 8: 1480-1495.