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• Passaro, VM. N.
• Dell’Olio, F
• Casamassima, B
• De Leonardis, F
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• Passaro, VM. N.
• Dell’Olio, F
• Casamassima, B
• De Leonardis, F
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• Passaro, VM. N.
• Dell’Olio, F
• Casamassima, B
• De Leonardis, F

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Sensors 2007, 7(4), 508-536; doi:10.3390/s7040508

Article

Guided-Wave Optical Biosensors

Vittorio M. N. Passaro ^1,* , Francesco Dell’Olio ¹ , Biagio Casamassima ¹  and Francesco De Leonardis ²

¹ Photonics Research Group, Dipartimento di Elettrotecnica ed Elettronica, Politecnico di Bari, via Edoardo Orabona n. 4, 70125 Bari, Italy ² Photonics Research Group, Dipartimento di Ingegneria dell’Ambiente e per lo Sviluppo Sostenibile, Politecnico di Bari, viale del Turismo n. 8, 74100 Taranto, Italy

* Author to whom correspondence should be addressed.

Received: 23 March 2007 / Accepted: 24 April 2007 / Published: 25 April 2007

(This article belongs to the Special Issue Optical Biosensors)

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Abstract: Guided-wave optical biosensors are reviewed in this paper. Advantages related to optical technologies are presented and integrated architectures are investigated in detail. Main classes of bio receptors and the most attractive optical transduction mechanisms are discussed. The possibility to use Mach-Zehnder and Young interferometers, microdisk and microring resonators, surface plasmon resonance, hollow and antiresonant waveguides, and Bragg gratings to realize very sensitive and selective, ultra-compact and fast biosensors is discussed. Finally, CMOS-compatible technologies are proved to be the most attractive for fabrication of guided-wave photonic biosensors.

Keywords: Biosensors; Surface Plasmon Resonance; Mach-Zehnder interferometers; Microdisk and Microring; Photonic technologies

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