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Sensors 2007, 7(4), 420-437; doi:10.3390/s7040420
Article

Modifications of Poly(o-phenylenediamine) Permselective Layer on Pt-Ir for Biosensor Application in Neurochemical Monitoring

1, 1, 1, 1, 1, 1, 1, 2,*  and 1,*
Received: 27 March 2007; Accepted: 10 April 2007 / Published: 12 April 2007
(This article belongs to the Special Issue Amperometric Sensors and Techniques for Neurochemical Monitoring)
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Abstract: Reports that globular proteins could enhance the interference blocking ability ofthe PPD (poly(o-phenylenediamine) layer used as a permselective barrier in biosensordesign, prompted this study where a variety of modifying agents were incorporated into PPDduring its electrosynthesis on Pt-Ir electrodes. Trapped molecules, including fibrous proteinsand β-cyclodextrin, altered the polymer/modifier composite selectivity by affecting thesensitivity to both H2O2 (signal molecule in many enzyme-based biosensors) and thearchetypal interference species, ascorbic acid. A comparison of electrochemical properties ofPt and a Pt-Ir alloy suggests that the benefits of the latter, more rigid, metal can be exploitedin PPD-based biosensor design without significant loss of backward compatibility withstudies involving pure Pt.
Keywords: Platinum-iridium electrodes; Polymer electrosynthesis; Cyclic voltammetry; Amperometry; Proteins; Cyclodextrins; Ascorbate; Hydrogen peroxide; Brain analysis. Platinum-iridium electrodes; Polymer electrosynthesis; Cyclic voltammetry; Amperometry; Proteins; Cyclodextrins; Ascorbate; Hydrogen peroxide; Brain analysis.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kirwan, S.M.; Rocchitta, G.; McMahon, C.P.; Craig, J.D.; Killoran, S.J.; O’Brien, K.B.; Serra, P.A.; Lowry, J.P.; O’Neill, R.D. Modifications of Poly(o-phenylenediamine) Permselective Layer on Pt-Ir for Biosensor Application in Neurochemical Monitoring. Sensors 2007, 7, 420-437.

AMA Style

Kirwan SM, Rocchitta G, McMahon CP, Craig JD, Killoran SJ, O’Brien KB, Serra PA, Lowry JP, O’Neill RD. Modifications of Poly(o-phenylenediamine) Permselective Layer on Pt-Ir for Biosensor Application in Neurochemical Monitoring. Sensors. 2007; 7(4):420-437.

Chicago/Turabian Style

Kirwan, Sarah M.; Rocchitta, Gaia; McMahon, Colm P.; Craig, Jennifer D.; Killoran, Sarah J.; O’Brien, Kylie B.; Serra, Pier A.; Lowry, John P.; O’Neill, Robert D. 2007. "Modifications of Poly(o-phenylenediamine) Permselective Layer on Pt-Ir for Biosensor Application in Neurochemical Monitoring." Sensors 7, no. 4: 420-437.



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