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• Kirwan, SM.
• Rocchitta, G
• McMahon, CP.
• Craig, JD.
• Killoran, SJ.
• O’Brien, KB.
• Serra, PA.
• Lowry, JP.
• O’Neill, RD.
• [+] on Google Scholar
• Kirwan, SM.
• Rocchitta, G
• McMahon, CP.
• Craig, JD.
• Killoran, SJ.
• O’Brien, KB.
• Serra, PA.
• Lowry, JP.
• O’Neill, RD.
• [+] on PubMed
• Kirwan, SM.
• Rocchitta, G
• McMahon, CP.
• Craig, JD.
• Killoran, SJ.
• O’Brien, KB.
• Serra, PA.
• Lowry, JP.
• O’Neill, RD.

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Sensors 2007, 7(4), 420-437; doi:10.3390/s7040420

Article

Modifications of Poly(o-phenylenediamine) Permselective Layer on Pt-Ir for Biosensor Application in Neurochemical Monitoring

Sarah M. Kirwan ¹ , Gaia Rocchitta ¹ , Colm P. McMahon ¹ , Jennifer D. Craig ¹ , Sarah J. Killoran ¹ , Kylie B. O’Brien ¹ , Pier A. Serra ¹ , John P. Lowry ^2,*  and Robert D. O’Neill ^1,*

¹ UCD School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland ² Sensors Development Unit, BioAnalytics Laboratory, Department of Chemistry, National University of Ireland, Maynooth, Co, Kildare, Ireland

* Authors to whom correspondence should be addressed.

Received: 27 March 2007 / Accepted: 10 April 2007 / Published: 12 April 2007

(This article belongs to the Special Issue Amperometric Sensors and Techniques for Neurochemical Monitoring)

Download PDF Full-Text [149 KB, uploaded 20 June 2008 16:51 CEST]

Abstract: Reports that globular proteins could enhance the interference blocking ability ofthe PPD (poly(o-phenylenediamine) layer used as a permselective barrier in biosensordesign, prompted this study where a variety of modifying agents were incorporated into PPDduring its electrosynthesis on Pt-Ir electrodes. Trapped molecules, including fibrous proteinsand β-cyclodextrin, altered the polymer/modifier composite selectivity by affecting thesensitivity to both H₂O₂ (signal molecule in many enzyme-based biosensors) and thearchetypal interference species, ascorbic acid. A comparison of electrochemical properties ofPt and a Pt-Ir alloy suggests that the benefits of the latter, more rigid, metal can be exploitedin PPD-based biosensor design without significant loss of backward compatibility withstudies involving pure Pt.

Keywords: Platinum-iridium electrodes; Polymer electrosynthesis; Cyclic voltammetry; Amperometry; Proteins; Cyclodextrins; Ascorbate; Hydrogen peroxide; Brain analysis.

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