Sensors 2007, 7(4), 420-437; doi:10.3390/s7040420
Article

Modifications of Poly(o-phenylenediamine) Permselective Layer on Pt-Ir for Biosensor Application in Neurochemical Monitoring

1 UCD School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland 2 Sensors Development Unit, BioAnalytics Laboratory, Department of Chemistry, National University of Ireland, Maynooth, Co, Kildare, Ireland
* Authors to whom correspondence should be addressed.
Received: 27 March 2007; Accepted: 10 April 2007 / Published: 12 April 2007
(This article belongs to the Special Issue Amperometric Sensors and Techniques for Neurochemical Monitoring)
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Abstract: Reports that globular proteins could enhance the interference blocking ability ofthe PPD (poly(o-phenylenediamine) layer used as a permselective barrier in biosensordesign, prompted this study where a variety of modifying agents were incorporated into PPDduring its electrosynthesis on Pt-Ir electrodes. Trapped molecules, including fibrous proteinsand β-cyclodextrin, altered the polymer/modifier composite selectivity by affecting thesensitivity to both H2O2 (signal molecule in many enzyme-based biosensors) and thearchetypal interference species, ascorbic acid. A comparison of electrochemical properties ofPt and a Pt-Ir alloy suggests that the benefits of the latter, more rigid, metal can be exploitedin PPD-based biosensor design without significant loss of backward compatibility withstudies involving pure Pt.
Keywords: Platinum-iridium electrodes; Polymer electrosynthesis; Cyclic voltammetry; Amperometry; Proteins; Cyclodextrins; Ascorbate; Hydrogen peroxide; Brain analysis.

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MDPI and ACS Style

Kirwan, S.M.; Rocchitta, G.; McMahon, C.P.; Craig, J.D.; Killoran, S.J.; O’Brien, K.B.; Serra, P.A.; Lowry, J.P.; O’Neill, R.D. Modifications of Poly(o-phenylenediamine) Permselective Layer on Pt-Ir for Biosensor Application in Neurochemical Monitoring. Sensors 2007, 7, 420-437.

AMA Style

Kirwan SM, Rocchitta G, McMahon CP, Craig JD, Killoran SJ, O’Brien KB, Serra PA, Lowry JP, O’Neill RD. Modifications of Poly(o-phenylenediamine) Permselective Layer on Pt-Ir for Biosensor Application in Neurochemical Monitoring. Sensors. 2007; 7(4):420-437.

Chicago/Turabian Style

Kirwan, Sarah M.; Rocchitta, Gaia; McMahon, Colm P.; Craig, Jennifer D.; Killoran, Sarah J.; O’Brien, Kylie B.; Serra, Pier A.; Lowry, John P.; O’Neill, Robert D. 2007. "Modifications of Poly(o-phenylenediamine) Permselective Layer on Pt-Ir for Biosensor Application in Neurochemical Monitoring." Sensors 7, no. 4: 420-437.

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