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Sensors 2006, 6(7), 727-745; doi:10.3390/s6070727

Mathematical Modeling of Plate−gap Biosensors with an Outer Porous Membrane

1,* , 1
1 Faculty of Mathematics and Informatics, Vilnius University, Naugarduko 24, LT−03225 Vilnius, Lithuania 2 Institute of Mathematics and Informatics, Akademijos 4, LT−08663 Vilnius, Lithuania 3 Institute of Biochemistry, Mokslininku 12, LT−08662 Vilnius, Lithuania
* Author to whom correspondence should be addressed.
Received: 26 April 2006 / Accepted: 11 July 2006 / Published: 24 July 2006
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A plate−gap model of a porous enzyme doped electrode covered by a porousinert membrane has been proposed and analyzed. The two−dimensional−in−spacemathematical model of the plate−gap biosensors is based on the reaction−diffusionequations containing a nonlinear term related to the Michaelis−Menten kinetics. Usingnumerical simulation of the biosensor action, the influence of the geometry of the outermembrane on the biosensor response was investigated at wide range of analyteconcentrations as well as of the reaction rates. The numerical simulation was carried outusing finite−difference technique. The behavior of the plate−gap biosensors was comparedwith that of a flat electrode deposited with a layer of enzyme and covered with the sameouter membrane.
Keywords: modeling; reaction−diffusion; simulation; biosensor. modeling; reaction−diffusion; simulation; biosensor.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Baronas, R.; Ivanauskas, F.; Kaunietis, I.; Laurinavicius, V. Mathematical Modeling of Plate−gap Biosensors with an Outer Porous Membrane. Sensors 2006, 6, 727-745.

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